哈萨克族人β_3受体和过氧化物酶增殖体激活受体γ_2基因复合变异与代谢综合征的关系

Additive effects of variants in β_3-adrenergic receptor and PPAR-γ_2 genes on metabolic syndrome and morbid obesity in Xinjiang Kazakh population

目的检测新疆哈萨克族人群中β3受体基因Trp64Arg多态和过氧化物酶增殖体激活受体γ2(peroxisome proliferators-activated receptorγ2,PPARγ2)基因Pro12Ala多态联合变异与单纯腹型肥胖和代谢综合征的关系。方法应用聚合酶链反应和限制性片断长度多态性技术检测代谢综合征159例,单纯腹型肥胖78例和正常人基因型106例,同时测定相关的生化指标,并进行统计学分析。结果Trp64Arg多态和Pro12Ala多态及两基因的联合变异的基因型和等位基因频率在3组间差异无统计学意义。结论β3受体Trp64Arg多态和PPARγ2的Pro12Ala多态及两基因的联合变异与哈萨克族人群腹型肥胖及代谢综合征无明显关联。

Objectives To investigate the additive effects of β3-AR gene Trp64Arg variation and peroxisome proliferators-aetivated receptor gamma 2 （PPART2） gne Pro12Ala variation on metabolic syndrome and morbid obesity in Xinjiang Kazakh Population. Methods PCR-restrietion fragment length polymorphism was used to detect the genotypes of 159 MBS and 78 alone morbid obesity and 106 controls, and some biochemical indices were tested. The associations of the polymorphisms with MBS and morbid obesity were assessed in a casecontrol study. Results No statistically significant differences were found in the frequencies of β3-AR or PPART2 gene mutation and simultaneously two genes mutation among the three groups. Conclusions Additive effects of the variants in the β3-AR Trp64Arg and PPART2Prol2Ala are not significantly associated with MBS and morbid obesity in xinjiang Kazakh population.