胺碘酮治疗充血性心力衰竭室性心律失常

Effect of amiodarone on ventricular arrhythmia in patients with congestive heart failure

目的了解胺碘酮对充血性心力衰竭(congestive heart failure,CHF)并发室性心律失常(ventricul ararrhythmia,VA)的疗效,并分析充血性心力衰竭心功能级别与室性心律失常的关系。方法选择心内科住院治疗的病人58例为研究对象,分为胺碘酮组和对照组。结果①心功能越差,复杂性心律失常的发生率越高。②胺碘酮组对心律失常治疗的有效率为93%,对照组为50%,差异有统计学意义(χ2=10.355,P=0.006);两组病人心功能参数各指标的差值无统计学意义(P<0.05);胺碘酮组与对照组对心力衰竭的疗效差异无统计学意义(χ2=4.047,P=0.132)。结论胺碘酮对CHF并VA病人疗效好且安全,值得在临床上推广。

Objectives To investigate the effect of amiodarone on congestive heart failure （CHF） with ventricular arrhythmia （VA）, and to explore the relationship of the grade of CHF and VA. Methods Fiftyeight patients treated in our hospital during January 2006 to January 2007 were selected as the study objects, and they were divided into observation group and control group. All patients were treated with routine methods, and they the patients in observation group were treated with amiodarone based on the routine methods. Results （1） The higher grade of heart function was, the higher incidence rate of complex ventricular arrhythmia occurred. （2）The effective rate of anti-arrhythmia was 93% in the observation group, but 50% in the control group, the difference had statistic significance （A-2=10.355, P=0.006） ; The cardiac function parameters between two groups were no statistic differences （P〉0.05）; The therapy effects for CHF in the two groups had no statistic differences （x^2=4.047, P=0.132）, Conclusions Amiodarone for treating CHF with VA is effective and safe, and valuable to wisely use in clinic.