摘要
目的研究在全麻手术患者中硫喷妥钠对丙泊酚药动学的影响,并与单用丙泊酚时比较。方法16名全麻手术患者分为2组,分别静注丙泊酚2mg.kg-1或1%丙泊酚和2.5%硫喷妥钠1:1等体积混合液0.2mL.kg-1(相当于丙泊酚1mg.kg-1,硫喷妥钠2.5mg.kg-1),用高效液相色谱法测定丙泊酚血药浓度。用3P97程序拟合计算药动学参数。结果静注丙泊酚的药-时曲线符合三室模型,单用组与合用组的药动学参数:t1/2α分别为(0.8±0.4)和(0.7±0.3)min,t1/2β分别为(10.2±15.6)和(6.5±5.0)min,t1/2γ分别为(113.0±47.2)和(159.0±82.5)min,Vc分别为(0.055±0.022)和(0.052±0.041)L.kg-1,CL分别为(17.4±4.5)和(15.5±8.3)mL.h-1.kg-1,AUC分别为(108.92±31.68)和(88.84±59.08)mg.min.L-1。结论二组患者间丙泊酚主要药动学参数的差异无统计学意义,与文献报道基本一致。
OBJECTIVE To study the effect of thiopental on pharmacokinetics of propotbl in patients undergoing general anesthesia. METHODS 16 Patients undergoing general anesthesia were divided into 2 groups randomly. After intravenous administration of propofol 2 mg· kg^-1 or 1% propofol and 2. 5% thiopental in a ratio of 1:1 volume mixture,the serum concentrations of propofol were measured by high performance liquid chromatography. The pharmacokinetic parameters of propotol were estimated by 3P97 program. RESULTS The serum concentration-time profiles of propotol were discribed by a three compartment model. The pharmacokinetic parameters for two groups were as follows: t 1/2α (0. 8 ± 0.4) and (0.7 ± 0. 3 )min, t 1/2β ( 10.2 ± 15.6) and (6.5 ± 5.0) min, t 1/2γ (113.0 ±47.2) and (159. 0 ±82. 5) min,Vc (0. 055 ±0.022) and (0. 052 ±0. 041) L·kg^-1 ,CL (17.4 ±4. 5) and (15.5±8.3) mL·h^-1· kg^-1 ,AUC (108.92 ±31.68) and (88.84 ±59.08) mg·min·L^-1 ,respectively. CONCLUSION No significant differences were found among the main pharmacokinetic parameters in two groups, which is in good accordance with that of the literature reports.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2008年第3期207-209,共3页
Chinese Pharmaceutical Journal
基金
全军“十一五”医药卫生科研基金科技攻关课题资助项目(06G023)
关键词
丙泊酚
药动学
高效液相色谱法
propofol
pharmacokinetics
high performance liquid chromatography HPLC