摘要
目的探讨不同剂量阿托伐他汀治疗对血管内皮功能及脑钠肽(BNP)水平的影响。方法在我院确诊的150例高血压病同时具有高脂血症患者随机分成A、B、C三组,分别接受10、20、40 mg/d阿托伐他汀治疗4周。比较3组血脂水平、血管内皮功能相关指标血管性假性血友病因子(vWF)及BNP水平。结果与治疗前比较,不同剂量阿托伐他汀治疗组vWF及BNP水平均明显下降,C组明显低于A、B组(P<0.01),3组不良反应相似。结论阿托伐他汀降脂治疗可改善高血压病患者的内皮功能,40 mg阿托伐他汀作用比较明显。
Objective To assess effects of atorvastatin on serum vWF and BNP in patient with hypertension. Methods 150 patients with hypertension combined with hyperlipoidemia were divided into group A, B and C randomly. They were treated by atorvastatin with the concentration of 10, 20, 40 mg/d respectively. The total period of treatment was 4 weeks. TC, TG, LDL-C, HDL-C, vWF, BNP were measured in disorder lipoidemic group of pretreatment and treatment after 4 weeks. Results The level of vWF and BNP after treatment were decreased significantly in all patients. The level of vWF and BNP in 40 mg/d group were lower than those in 10 group and 20 mg/d group. Conclusion Atorvanstain may significandy reduce lipid and improve endothelial function in hyperlipoidemic patients. 40mg/d atorvastatin has better effect.
出处
《山东医药》
CAS
北大核心
2008年第1期13-15,共3页
Shandong Medical Journal
基金
河北省卫生厅科研立项课题(07430)
