雌激素受体基因多态性与帕金森病的相关性研究

Association between estrogen receptor gene polymorphisms and Parkinson's disease

目的探讨中国汉族人群中雌激素受体(ER)基因多态性与帕金森病(PD)发病的关系。方法采用聚合酶链式反应(PCR)和限制性片断长度多态(RFLP)方法,于158例PD患者和146例正常人中检测ER多态各基因型和基因频率的分布,按比值比(OR)作疾病关联分析。结果PD组ER分别经XbaⅠ、PvuⅡ酶切后,各基因型频率、单个等位基因频率与对照组比较均无统计学差异(P>0.05)。中国汉族PD人群中,ER基因型以xx、pp型最多,而XX、PP型最少。结论中国汉族人群中,ER存在着ER XbaⅠ和PvuⅡ基因多态性,但与PD的发病风险不相关。

Objective To explore the relationship of estrogen receptor gene polymorphism and Parkinson＇ s disease in Hans population. Methods The ER gene polymorphism was detected in 158 PD cases and 146 healthy subjects with polymerase chain reaction （PCR） method and restriction fragment length polymorphism （RFLP） genotyping technique. The odds ratio was used for association analysis. Results In PD group, ER was used by Xba Ⅰ and Pvu Ⅱ restriction enzyme respectively. There were no significant differences in the genotype or allele frequencies between PD cases and controls （P ：〉0.05）. In Hans PD group, ＂pp＂ and ＂xx＂ accounted the most, while ＂PP＂ and ＂XX＂ accounted the least. Conclusions There are no significant differences in the genotype or allele frequencies between PD cases and controls. The ER gene polymorphism is not related to the risk for PD in Chinese Hans.