蛴螬提取物抗肿瘤作用的体外血清药理学实验

Sero-pharmacological experiment of anti-tumor effect of the grub extract in vitro

目的探讨蛴螬提取物对人肺癌A549和人宫颈癌HeLa细胞株抗肿瘤作用。方法采用血清药理学实验方法,观察含药血清体外对人肺癌A549和人宫颈癌HeLa细胞株抗增殖作用。结果血清药理学实验结果显示,终浓度分别为20%、25%的灭活的蛴螬提取物含药大白鼠血清对A549细胞株的增殖抑制率分别为18.92%、37.54%;终浓度分别为10%、20%、25%的灭活的蛴螬提取物含药血清对HeLa细胞株的增殖抑制率分别为39.86%、24.86%及26.60%。结论蛴螬提取物含药血清对人肺癌A549和人宫颈癌HeLa细胞株增殖有抑制作用。

Objective To investigate the anti-tumor effect of the grub extract on the A549 human lung cancer and HeLa human cervical carcinoma. Methods Anti-proliferation effect of the grub extract to the A549 human lung cancer and HeLa human cervical carcinoma was observed by serum pharmacology method. Results The growth inhibition rates of A549 cells treated by inactivated grub extract-containing rat serum with concentration of 20% and 25% were 18.92% and 37.54% respectively. The growth inhibition rates of HeLa cells treated by inactivated grub extract-containing rat serum with concentration of 10%, 20% and 25% were 39. 86 %, 24. 86% and 26. 60% respectively. Conclusion The grub extract-containing serums have the effect on anti-proliferation of A549 lung cancer cell line and HeLa cell line.