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青霉素类过敏反应与特异性IgE抗体的研究

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摘要 采用放射过敏原吸附试验法检测248例青霉素过敏患者和101例正常人血清中4种药物青霉素G、青霉素V、氨苄西林和阿莫西林(PG、PV、AP、AX)的8种抗原决定簇特异性IgE抗体。发现青霉素过敏患者血清中特异性IgE抗体总的阳性率为57.26%;过敏性休克和荨麻疹患者中PG的阳性率最高,其他症状患者中PV阳性率最高;只检测BPO-IgE一种抗体的阳性率(21.37%)低于检测8种抗体(57.26%);过敏患者特异性IgE抗体阳性率随时间的延长呈下降趋势。认为青霉素过敏患者血清中存在次要抗原决定簇IgE抗体,与主要抗原决定簇一样发挥着重要作用。
作者 杨静 乔海灵
出处 《山东医药》 CAS 北大核心 2008年第1期79-80,共2页 Shandong Medical Journal
基金 河南省杰出青年基金资助项目(0312002100) 河南省自然科学基金资助项目(0211040100) 河南省医学创新人才工程项目(2002114)。
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