转录调节因子Ets-1在食管鳞癌的表达及其意义

Expression and its significance of transcription factor Ets-1 in esophageal squamous cell carcinomas

目的：探讨转录调节因子Ets-1在食管鳞癌组织的表达及其意义。方法：采用免疫组化技术（SP法）检测Ets-1在68例食管鳞癌组织及癌旁组织中的表达。结果：Ets-1在食管癌肿瘤组织高表达,远高于癌旁组织（P〈0.005）;Ets-1在肿瘤组织阳性表达率在不同病理分级、TNM分期各组中,差异均有统计学意义（P〈0.05-P〈0.01）,而且Ets-1阳性表达率与病理分级、淋巴结转移和TNM分期均呈正相关关系（P〈0.05-P〈0.01）。未发现Ets-1在食管癌肿瘤组织的阳性表达率与病理类型有关（P〉0.05）。结论：Ets-1在食管癌组织高表达,并与病理学分级、淋巴结转移及TNM分期有关。

Objective：To analyze the expression and its significance of Ets-1 （E26 transformation-specific） in esophageal squamous cell carcinomas（ESCC）. Methods：Tissue samples were collected from 68 patients who underwent surgery in our hospital from 1999 to 2005. The expression of Ets-1 in these samples by immunohistochemistry was detected. Results. Ets-1 protein expressed in esophageal carcinoma tissues is significantly higher than in pericaneerous tissues（P 〈 0. 005 ）. The expression of Ets-1 is positively correlated with the pathology grading,lymph node metastasis, and TNM stage of ESCC （P 〈 0.05 ）. The pathological type were no association with the Ets-1 protein expression positive rates in ESCC. Conclusions ：The results indicated that Ets-1 was over expressed in ESCC tissues and correlated with its pathology grading,lymph node metastasis and TNM stage.