同步辐射衍射增强成像的肝纤维化成像研究

Investigation of hepatic fibrosis with synchrotron X-ray diffraction enhanced imaging

本文根据硬X射线衍射增强成像(Diffraction enhanced imaging,DEI)原理,对由人血白蛋白诱导的大鼠肝纤维化模型进行了成像研究。实验在北京同步辐射装置(Beijing Synchrotron Radiation Facility,BSRF)4W1A光束线形貌站完成。结果表明:正常及不同程度肝纤维化模型在DEI图像上差异显著,图像感兴趣区的光强分布及纹理测度也显示出这种差异。DEI成像为肝纤维化的诊断提供了一种潜在的影像学途径。

In this paper, imaging investigation of hepatic fibrosis in rats induced by human albumin with hard X-ray diffraction enhanced imaging （DE1） is reported. The experiments were performed at 4W1A beamline of Beijing Syn- chrotron Radiation Facility （BSRF）. The results show that great differences can be observed in DEI images between the normal and diseased rats in different stages of liver fibrosis. The difference can also be revealed by the profile curve and texture measurements on regions of interest. The results show that DEI may be a potential way for diagnosis of hepatic fibrosis.