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nm23-H_1、CD44v6在食管鳞状细胞癌中的表达及临床意义

The expression and its clinical significance of nm23-H_1 and CD44v6 in esophageal squamous cell carcinoma
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摘要 目的探讨肿瘤转移抑制基因nm23-H1、细胞粘附分子变异型CD44v6在食管鳞癌组织中的表达及临床意义。方法采用免疫组化SP法,检测54例食管鳞癌手术标本nm23-H1蛋白、CD44v6蛋白表达,分析其表达与食管鳞癌生物学特性及临床特点之间关系。结果淋巴结转移组与无淋巴结转移组相比,nm23-H1表达降低,CD44v6表达增强;大于3年生存组与小于3年生存组相比,nm23-H1表达增强,CD44v6表达降低;nm23-H1表达与肿瘤浸润深度和临床分期呈负相关;CD44v6表达与肿瘤浸润深度和临床分期呈正相关。结论nm23-H1表达降低、CD44v6表达增强与食管鳞癌浸润转移有一定相关性。 Objective To study the expression and its clinical significance of nm23 - H1 and CD44v6 in human esophageal squamous cell carcinoma. Methods The expressions of nm23 - H1, CD44v6 were detected by immunohistochemical SP methods in tissue samples from 54 cases of ESCC who received surgery operation only. Results The result showed that the nm23 - H1, CD44v6 expressions were related to primary tumor invasion, metastasis of lymphnodes, clinical stage and 3 - year survival rate. Conclusion nm23 - H1, CD44v6 might be important biological markers in ESCC and they might be related to the biological behavior of ESCC.
作者 李海亮 高平 张宁妹
机构地区 宁夏医学院 宁夏医学附属医院
出处 《宁夏医学杂志》 CAS 2008年第2期111-113,共3页 Ningxia Medical Journal
关键词 NM23-H1 CD44V6 食管鳞癌 表达 临床意义 nm23 - H1 CD44v6 Esophageal squamous cell carcinoma Expression
分类号 R735.1 [医药卫生—肿瘤]
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参考文献10

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宁夏医学杂志
2008年 第2期

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