颈动脉粥样硬化的超声检查与其危险因素的关系研究

Study on the relationship between carotid atherosclerosis by ultrasonography and its risk factors

目的探讨用超声检测颈动脉内-中膜厚度的方法,分析颈动脉粥样硬化与其危险因素的关系。方法二维超声检查97例颈动脉粥样硬化患者和68例正常人颈动脉内-中膜厚度及斑块的大小,并对血清总胆固醇(TC)、载脂蛋白AI(apoAI)、apoB、纤维蛋白原(FIB)、C-反应蛋白(CRP)等水平在两组间比较。结果(1)颈动脉粥样硬化组血脂、FIB、CRP水平高于对照组;(2)FIB、CRP水平增高与颈动脉硬化患者斑块指数级别有明显关系;(3)Spearsm an相关分析显示CRP、FIB、LDL-C等水平升高与颈动脉粥样硬化呈显著正相关,多因素回归分析发现颈动脉粥样硬化与FIB、LDL-C等水平升高有关。结论CRP、脂质、FIB水平升高与颈动脉粥样硬化的严重程度有密切关系,颈动脉粥样硬化病变与多种脑血管病危险因素的聚集有显著相关性。

Objective To measure the intima - media thickness （IMT） of bilateral carotid arteries with ultrasonography and to assess the relationship of carotid atherosclerosis （CAs） and its main risk factors. Methods All subjects were divided into CAs group and non - CAs group. Carotid intima - media thickness and the size of carotid plaque were detected by 2 - dimensional ultrasound. Many potential risk factors of carotid atherosclerosis were compared between the two groups. Results Patients with severe carotid atherosclerosis had significant increased serum levels of lipid, C - reactive protein and plasma fibrinogen. There was a significant positive correlation between grades of carotid plaque with the serum levels of C - reactive protein, fibrinogen. Patients who had significant elevated plasma levels of lipoprotein, C - reactive protein, fibrinogen had significantly higher incidence and more severity of carotid atherosclerosis, Conclusion The elevated levels of C - reactive protein, lipid, fibrinogen are closely correlated with carotid atherosclerosis and its severity.