摘要
白色念珠菌病对人类的健康有很大威胁,虽然已经有了一些治疗性药物(如氟康唑、两性霉素等),但其发生率和死亡率都居高不下。目前认为,抗真菌疫苗是未来治疗真菌疾病的新途径。本文综述了近年来白色念珠菌疫苗基础性研究的进展,概述了几种正在研究中的白色念珠菌疫苗。
出处
《药学实践杂志》
CAS
2008年第1期5-6,10,共3页
Journal of Pharmaceutical Practice
参考文献18
-
1Saarela HI, Jousimies H, Takala A, et al. Age-relaed acquisition of oral and nasopharyngeal yeast species and stability of colonization in young children [ J ]. Oral Microbiol Immunol, 1999, 14 (3) :176.
-
2Kojic EM, Darouiche RO. Candida infections of medical devices [J]. Clin Microbial Rev, 2004, 17(2) : 255.
-
3Comely OA, Ullman A J, Karthaus M. Evidence-based assessment of primary antifungal prophylaxis in patients with hematologic malignancies [ J ]. Blood,2003,101 (9) :3365.
-
4Carla B, Antonella T, Chiani P,et al. Interplay between protective and inhibitory antibodies dictates the outcome of experimentally disseminated candidiasis in Recipients of a candida albicans vaccine [J]. Infect Immun, 2002,70(10) :5462.
-
5Levy R, Segal E, Eylan E. Protective immunity against murine candidiasis elicited by Candida albicans ribosomal fractions [ J]. Infect Immun,1981,31 (3) :874.
-
6Eckstein M, Barenholz Y, Bar LK, et al. Liposomes containing candida atbicans ribosomes as a prophylactic vaccine against disseminated candidiasis in mice[J]. Vaccine, 1997,15:220.
-
7Han Y, Cutler JE. Antibody response that protects against disseminated candidiasis [ J]. Infect Immun, 1995,63 ( 7 ) :2714.
-
8Han Y, Ulrich MA, Cutler JE. Candida albicans mannan extract-protein conjugates induce a protective immune response against experimental candidiasis [ J ]. Infect Dis, 1999,179 ( 6 ) : 1477.
-
9Polonelli L, Magliani W, Conti S, et al. Therapeutic activity of an engineered synthetic killer antiidiotypic antibody fragment against experimental mucosal and systemic candidiasis [ J ]. Infect Immun ,2003,71 ( 11 ) :6205.
-
10Polonelli L, Lorenzini R, De Bemardis F,et al. Idiotypic vaccination: immunoprotection mediated by anti-idiotype antibodies with antibiotic activity [ J ]. Immunol, 1993, 37 ( 1 ) : 105.
二级参考文献19
-
1Tang DC et al. Nature, 1992;356:152- 154
-
2Galgiani JN et al. Ann Intern Med, 1999; 130:293- 300
-
3Polonelli L et al. Med Mycol,2000;38 Suppl 1:281 - 292
-
4Kirkland TN et al. Infect Immun, 1998;66:3519- 3522
-
5Raed O et al. Infect Immun, 1999; 67(6) :2935 - 2940
-
6Cheng YJ et al. Infect Immun, 1999;67(2) :630 - 635
-
7Zhu Y et al. Gene, 1996 ;181:121 - 125
-
8Tighe H et al. Immunol Today, 1998; 19:89 - 97
-
9Cheng YJ et al. Infect Immun;1999;67(11) :5848 - 5853
-
10Homer AA et al. Cell Immunol, 1998; 190:77 - 82
同被引文献26
-
1廖万清,顾菊林.医学真菌学研究的现状与展望[J].国际皮肤性病学杂志,2006,32(2):65-66. 被引量：2
-
2Ana Conde-Rosa, Rosana Amador, Doris Perez-Torres, et al. Candidemia distribution, associated risk factors, and attributed mortality at a universi- ty-based medical center[J]. P R Health Sci J,2010 ;29( 1 ) :26-9.
-
3Sheppard DC ,Rieg G. Novel inhalational murine model of invasive pulmo- nary aspergillosis [J]. Antimicrob Age Chemother,2004 ;48 (5) : 1908-11.
-
4Ashman RB, Vijayan D, Wells CA. IL-12 and related 'cytokines : function and regulatory implications in Candida albicmls infection[J]. Clin Devel Immuno1,2011 ;2011:686597.
-
5Mitra S, Dolan K, Foster TH, et al. Imaging morphogenesis of Candida albicans during infection in a live animal [J]. Biomedi Optics,2010;15(1) :104-5.
-
6Tsuchimori N, Sharkey LL, Fonzi WA,et al. Redued virulence of HWP1- deficient mutants of candida albicans and their interactions with host cells[J]. Infec [mmun,2000 ;68 (4) : 1997-2002.
-
7Xu XL, Zhu Y, Wang Y. Bacterial peptidoglycan triggers eandida albi- cans hyphal growth by directly activating the adenylyl cyclase Cyrl p [J] Cell Host & Microb,2008 ;4( 1 ) :28-39.
-
8Klengel T, Liang WJ, Chaloupka J, et al. Fungal adenylyl eyelase in- tegrates CO2 sensing with cAMP signaling and virulence[ J]. Curr Biol, 2005 ;15(22) :2021-6.
-
9Gasparoto TH ,Tessarolli V. Absence of functional TLR4 impairs of mac- rophages after Candida albicans infection [J] . Med Mycol, 2010 ; 48 (8) :1009-17.
-
10Huang W, Na L, Fidel PL, et al. Requirement of IL-17A for systemic an- ti-Candida albicans host defense in mice [J]. J Infect Dis, 2004;190 (3) :624-31.
二级引证文献4
-
1邱显鹏.侵袭性白色念珠菌肺部感染患者的生存分析[J].牡丹江医学院学报,2014,35(4):49-50.
-
2苏科文,陈静.重度支气管哮喘并发肺部真菌感染危险因素分析[J].成都医学院学报,2019,14(3):322-324. 被引量：13
-
3韩馨乐,戴嘉婧,郑雅丹,钟福波,林哲广,江淑祺,尹为华,方征宇.白色念珠菌在动物感染模型中的研究进展[J].医学动物防制,2020,36(10):944-947. 被引量：5
-
4邓洁华,王刚生,张晓光,罗静娜,王佳,祁晓明,李艳玲.免疫抑制BALB/c小鼠侵袭性白念珠菌感染动物模型的建立[J].医学动物防制,2021,37(9):838-841. 被引量：1
-
1熊思东,徐薇.DNA疫苗的研究进展[J].中国处方药,2003,2(2):22-26. 被引量：7
-
2王玉和,陈永艳.3种唑类药物治疗甲癣真菌病的成本-效果分析[J].中国临床药理学杂志,2004,20(6):419-419.
-
3李瑛.基础性研究为我省新药开发提供了有力的支持[J].云南科技管理,1999,12(6):11-12.
-
4王毅超,邹全明.幽门螺杆菌疫苗的研究进展[J].国外医学（药学分册）,2004,31(2):97-100. 被引量：2
-
5郭祖德,魏艳,陈英耀.卡泊芬净治疗侵袭性真菌疾病的药物经济学综述[J].中国药物评价,2016,33(6):517-520.
-
6孙永年,黄长形,徐哲.丙型肝炎疫苗的研究进展[J].国外医学（流行病学．传染病学分册）,2002,29(5):266-268. 被引量：2
-
7张庆平,符垚.中药软胶囊热的思考[J].中国执业药师,2006(8):12-13. 被引量：3
-
8陈列胜.流行性感冒病毒疫苗的研究进展[J].江苏卫生保健,2002,4(2):60-60. 被引量：1
-
9陈敏,史久华.自身免疫病疫苗[J].国外医学（预防．诊断．治疗用生物制品分册）,2000,23(5):218-221.
-
10谷莹,逢凤姣,任雪莲,高岚.抗乙肝药物研究进展[J].辽宁医药,2007,22(3):25-29. 被引量：3
