热休克蛋白与器官移植

Heat Shock Proteins and Organ Transplantation

热休克蛋白(HSPs)是一组主要存在细胞内、结构高度保守的蛋白质分子家族,具有抗炎症、抗细胞凋亡和减轻过氧化作用,对移植器官保存和缺血再灌注损伤发挥自身保护作用。同时,在生理条件下,HSPs也存在于细胞间隙,调控炎症和排斥反应的过程。HSPs适当的表达可能会减轻炎性反应,从而抑制移植排斥;另一方面,HSPs也可激活天然免疫系统和获得性免疫系统,加重移植排斥反应。HSPs对器官移植排斥的确切作用仍需进一步探索。

Heat shock proteins（HSPs） are ubiquitously expressed and highly conserved families of molecules. It has been proved that the characteristics of anti-inflammatory, anti-apoptosis and anti-peroxidation were self-protective to isehernia reperfusion injury （IRI） and the conservation of organ transplantation. HSPs are present in the extracellular environment under physiological conditions, which regulate the procedure of inflammation and rejection due to their role as intercellular signaling molecules. The induction of self heat shock protein immune reactivity can attenuate inflammatory reaction and delay transplant immunity. On the other hand, HSPs can also exacerbate transplant immunity by activating innate immunity system and adaptive immunity system. It needs to be explored further on the exact roles of liSPs in the field of organ transplantation.