摘要
脱嘌呤/脱嘧啶核酸内切酶1(APE1)是一个生物大分子功能复合体,既具有脱嘌呤/脱嘧啶位点(AP位点)核酸内切酶活性,又具调节转录因子的活性。其分布及单核苷酸多态性为近年来研究的热点。探讨其单核苷酸多态性与肿瘤的关系将有助于对肿瘤的防治。
Apurinc/apyrimidinic endonuclease 1/redoxfactor 1 is a functional complexity of a biological macromolecule, with both endonuclease activation for apurinc/apyrimidinic sites and mediating ability of transcription factor. In recent years, it is hot on the research of its distribution and SNPs. In this aritcle, we mainly reviewed advances in the correlationship study of the single nucleotide polymorphisms with cancer. It will be helpful in prevention and control of cancer to study on the relationship between its SNPs and cancer.
出处
《医学综述》
2008年第3期340-342,共3页
Medical Recapitulate
基金
福建省自然科学基金项目(C0610021
2006J0099)
