血管生成素在肿瘤中的研究

Studies on Angiopoietin in Tumor

血管生成素(Ang)是近年来发现的惟一含有受体激动剂和受体抑制剂的血管生长因子家族。作用于内皮特异受体酪氨酸激酶酪氨酸激酶受体2。Ang及其受体在肿瘤组织中的表达明显高于周围正常组织,且特异表达于肿瘤边缘的血管重建区,参与肿瘤新生血管的形成、延续,影响肿瘤的生长、转移,有望成为一种新的抗肿瘤血管新生的靶向分子。

Angiopoietin was fotmd in recent years, and it is the only family of angiogenic factors which contains activator and antagonist of receptor. Angiopoietin acts on Tie-2, which is a receptor tyrosine kinase specifically expressed on endothelial cells. The expression of angiopoietin and Tie-2 in the tumor tissue are higher than that in the normal tissue around the tumor,and specifically express on the domain of vascular remodeling of tumor margin. It and its receptor are not only involved in tumor angiogenesis and development,but also influence tumor growth and metastasis, which maybe become a new target molecule for antiangiogenesis of tumor.