活性氧簇介导的信号转导通路与糖尿病肾病

Signal Transduction Pathway Mediated by Reactive Oxygen Species and Diabetic Nephropathy

糖尿病时,在高糖等一系列致病因素的作用下,将导致肾小球系膜细胞和小管上皮细胞活性氧产生增多,抗氧化物质减少,不仅对机体造成氧化损伤,而且使蛋白激酶C、丝裂原活化蛋白激酶以及蛋白酪氨酸激酶/信号转导子和转录激活子通路活化增加而上调多种细胞因子的表达,使细胞外基质合成增加,降解减少,促进了糖尿病肾病的发生与发展。而抗氧化治疗则能减轻糖尿病肾病患者的肾损伤,为其临床治疗提供了又一新的策略。

During diabetes,mesangial cell and tubule epithelium will produce excessive reactive oxygen species, decreased antioxygen materials under fire action of series of etiological factors, such as, high glucose and so on. This could not only lead to oxidative damage to the body,but also increase the activation of signal transduction cascade （protein kinase C,mitogen-activated protein kinases, and janus kinase/signal transducers and activators of transcription） and upregulate the expression of several cytokines, which will result in increased synthesis and decreased degradation of extracellular matrix,and then promote the genesis and development of diabetic nephropathy. Antioxygen therapy can reduce the renal injury of diabetic nephropathy, and can provide an new clinical therapeutic strategy.