摘要
目的研究呕必宁冲剂急性毒性,确定其安全范围。方法应用呕必宁冲剂提取液给小鼠灌胃,测定小鼠的LD50或最大耐受量,观察动物所出现的毒性反应。结果用药组与对照组比较,体质量变化与各个脏器指数变化无显著差异(P>0.05)。结论呕必宁冲剂毒性很小,可供临床应用及实验研究。
Object To study the acute toxicity of Oubining powder preparation for infusion and determine margin of safety. Method The mouse had been administered by extract of Oubining powder preparation for infusion, determining LD50 or maximum tolerable dose, observing toxic reaction. Result There is no significance of diversity of weight,and so the index of organ. Condusion The toxicity of Oubining powder preparation for infusion is not strong, so it can be applied in clinical application and empirical study.
出处
《医学综述》
2008年第3期476-477,共2页
Medical Recapitulate
基金
辽宁省教育厅资助课题(20040228)
关键词
呕必宁冲剂
急性毒性
实验研究
Oubining powder preparation for infusion
Acute toxicity
Empirical study
