黄芩苷药理作用研究新进展

New research progress in pharmacological activities of baicalin

目的介绍黄芩苷药理作用研究新进展。方法根据发表的相关黄芩苷的文献进行综述。结果黄芩苷除了传统的镇静、降压、清除自由基、抗心律失常等作用外,还发现其具有抗肺炎衣原体所致的动脉粥样硬化作用,对缺血再灌注损伤的大脑和心肌具有保护作用,对不同原因引起的肝损伤具有保护作用,能显著促进成纤维细胞增殖,对人牙周膜成纤维细胞具有保护作用,在体外对某些寄生虫均有明显的抑制和杀灭作用。结论黄芩苷的开发利用主要是应用其抗炎、降压等活性,对其他药理活性的研究利用相对较少;黄芩苷还具有广泛的药理活性,如缺血再灌注损伤的保护作用、肝损伤的保护作用等,有着广泛的开发与应用前景。

Objective To review the new research progress in some pharmacological activities of baicalin. Methods Reviews were done based on relative references about baicalin. Results Except for traditional effects of baicalin on sedation, hypotension, clearance of free radical and antiarrhythmia, baicalin was proved to possess the therapeutic effects on arteriosclerosis caused by chlamydia pneumoniae, protective effects on ischemia reperfusion injury of brain, heart and hepatic injury induced by different causes, human periodontal ligament fibroblasts;baicalin could significantly inhibit trichomonas vaginalis in vitro. Conclusions This review provides a reference for the research and development of baicalin.