干燥综合征NOD小鼠模型研究进展

Advances in Research on the Pathology of Sjgren's Syndrome with the NOD Mouse Model

回顾国外NOD小鼠模型研究干燥综合征病理所取得的成果。查阅PUBMED上自2000年以来的相关文献,发现研究成果为疾病早期的细胞凋亡和疾病期的自身免疫反应提供了有利的证据。说明NOD小鼠模型在干燥综合征的病理机制研究中具有重要的作用,同时新抗原受体的发现为今后的研究提供了方向。

Objective The aim of this paper was to review the recent progress in research on the pathology of Sjogren＇ s syndrome with the NOD mouse model reported in the literature. Evidence has been provided to be favor for apoptosis in the early stage of the disease and autoimmune response of the illness. It is demonstrated that the NOD mouse model is very important in studying on the pathological mechanism of Sj gren＇ s syndrome and meanwhile, the recovery of new antigen-receptor directs the way to future researching.