女性反复泌尿系感染激素辅助治疗与常规治疗的对照研究

Clinical comparison of assisted treatment of recurrent urinary tract infeciton in postmentopausal women with steoids.

目的探讨环丙沙星联合替勃龙治疗绝经后妇女反复泌尿系感染的疗效和安全性。方法选择96例绝经后反复泌尿系感染的患者,随机分成2个组。环丙沙星联合替勃龙治疗组(A组):给予口服环丙沙星500mg/次,1d2次,连服7d,同时予口服替勃龙2.5mg/次,1d1次,连服3个月;环丙沙星治疗组(B组):给予口服环丙沙星500mg/次,1d2次,连服7d,每月1次,共用3个月。随访6个月,比较治疗3个月后两组各临床参数的变化和随访期病情复发率。结果治疗3个月后,总有效率、血清雌二醇水平、阴道健康评分A组均显著高于B组(P<0.01),复发率、阴道pH值A组均显著低于B组(P<0.01),子宫内膜厚度两组无显著性差异(P>0.05)。结论环丙沙星联合替勃龙治疗绝经后妇女反复泌尿系感染安全、有效,值得在临床推广应用。

Objective To evaluate the efficacy and safety of ciprofloxacin combined with tibolone in postmenopausal women with recurrent urinary tract infection （UTI）. Methods There 96 cases of postmenopausal women with recurrent UTI were randomly divided into group A consisted of 49 cases and treated with Ciprofloxacin combined with tibolone （with the dose of ciprofloxacin 500mg, po, bid, for 7 days, and tibolone 2.5mg, po, qd, for 3 months） and group B consisted of 47 cases and treated with ciprofloxacin （with the dose of ciprofloxacin 500mg, po, bid, for 7 days, once every month, and continuous use for 3 months）. The cases werer followed up for 6 months. The changes of clinical parameters 3 months after treatment and recurrent rate during the subsequent period of survey between 2 groups were compared. Results The total effective rate, the level of serum estrogen and vaginal health score （VHS） in group A three months after treatment were significantly higher than that of group B （ P 〈 0.01 ） ; the recurrent rate and pH of vagina in group A were significantly lower than that of group B （ P 〈 0.01 ） ; there no significant statistical differences were observed in changes of endometrial thickness between 2 groups. Conclusion Ciprofloxacin combined with tibolone is secure and effective on postmenopausal women with recurrent UTI, and it is worthwile to be popularized for clinical application.