摘要
目的:研究EG-1基因在甲状腺癌组织中的表达并分析其与预后的关系,为评价甲状腺癌的预后提供分子生物学标记。方法:用RT-PCR方法检测52例甲状腺癌组织中EG-1基因表达情况,分析比较EG-1基因表达组(38例)和未表达组(14例)的生存资料。同时与良性甲状腺疾病组织(15例)进行对照。结果:甲状腺癌组织中存在EG-1基因的表达,甲状腺良恶性组织EG-1基因表达具有统计学差异(P<0.05)。甲状腺癌EG-1基因表达组和未表达组生存率有统计学差别(P<0.05)。EG-1基因表达组预后差,与未表达组死亡风险危险度比值为4.947(P<0.05)。结论:甲状腺癌组织中存在EG-1基因的高表达,且EG-1基因表达组预后差。EG-1基因可能成为评价甲状腺癌预后的重要的分子生物学标记。
Objective：To study the expression of EG-1 in thyroid cancer tissue and analyze its correlation with clinical prognosis. Methods：EG-1 mRNA levels in malignant thyroid tissues were evaluated by RT-PCR. All patients were followed up. The survival rates were analyze in EG-1 positive group and EG-1 negative group. Benign thyroid tissues were used as control. Results：EG-1 was expressed in thyroid cancer. The differences between expression of malignant thyroid tissues and benign thyroid tissues were statistically significant （P〈0. 05）. In thyroid cancer, the survival rate differences between negative and positive groups of EG-1 had statistical significance （P〈0.05）. EG-1 positive group was with bad prognosis. Conclusion：EG-1 was expressed in thyroid cancer and might be used as an important prognostic marker.
出处
《中国现代普通外科进展》
CAS
2008年第1期36-39,共4页
Chinese Journal of Current Advances in General Surgery
基金
山东省自然基金项目(y2006c66)
