PPAR-γ的生物学特性及其配体治疗垂体腺瘤的研究进展
Biological characteristics of PPAR-γ and experimental treatment of pituitary adenomas with PPAR-γ ligands
摘要
过氧化物酶体增殖物激活受体-γ（peroxisome proliferator-activated receptor gamma．PPAR-γ）不仅对细胞生长、分化以及炎症、凋亡具有重要影响．而且与肿瘤细胞的生长密切相关。近年来。对于PPAR-γ及其配体的研究较多．取得了许多进展。本文就近年来关于PPAR-γ的生物学特性及其配体——噻唑烷二酮类药物（thiazolidinediones．TZDs）实验治疗垂体腺瘤（pituitary adenoma，PA）的研究进展作一综述。
出处
《中华神经医学杂志》
CAS
CSCD
2008年第2期200-202,共3页
Chinese Journal of Neuromedicine
参考文献20
-
1Schmidt A, Endo N, Rutledge SJ, et al. Identification of a new member of the steroid receptor superfamily that is activated by a peroxisome proliferators and fatty acid[J]. Mol Endocrinol, 1992, 6 (10): 1634-1641.
-
2Mukherjee R, Jow L, Croston GE, et al. Identification, characterization and tissue distribution of human pesoxisome proliferator activated receptor (PPAR) isoforms PPAR gamma2 versus PPAR gammal and activation with retinoid X receptor agonists and antagonists[J]. J Biol Chem, 1997, 272(12): 8071-8076.
-
3Tontonoz P, Hu E, Graves RA, et al. mPPAR-gamma2: tissuespecific regulator of an adipocyte enhancer[J]. Genes Dev, 1994, 8 (10): 1224-1234.
-
4Shao D, Lazar MA. Pesoxisome proliferators-activated receptorgamma, CCAAT/enhancer-binding protein alpha and cell cycle status regulate the commitment to adipocyte differentiation [J]. J Biol Chem, 1997, 272(34): 21473-21478.
-
5Sears I, Macginnitie MA, Kovacs LG, et al. Differentiation dependent expression of the brown adipocyte uncoupling protein gene:regulation by pesoxisome proliferators-activated receptor gamma[J]. Mol Cell Biol, 1996, 16(7): 3410-3419.
-
6Shi au CW, Yang CC, Kulp SK, et al. Thiazolidcnediones mediate apoptosis in prostate cancer cells in part through inhibition of Bcl-xL/Bcl-2 functions independently of PPAR-γ [J]. Cance Res, 2005, 65(4): 1561-1569.
-
7Chang TH, Szabo E. Induction of differentiation and apoptosis by ligands ofperoxisome proliferator-activated receptor-γin non-small cell lung cancer[J]. Cancer Res, 2000, 60(4): 1129-1138.
-
8Huang JW, Shiau CW, Yang YT, et al. Peroxisome proliferatoractivated receptor -γ-independent ablation of cyclin D1 by thiazolidinediones and their derivatives in breast cancer cells [J]. Mol Pharmacol, 2005, 67(4): 1342-1348.
-
9Chen F, Harrison LE. Ciglitazone-induced cellular anti proliferation increases p27kipl protein levels through both increased transcriptional activity and inhibition of proteasome degradation[J]. Cell Signal, 2005, 17(7): 809-816.
-
10Chen F, Kim E, Wang CC, et al. Ciglitazone-induced p27 gene transcriptional activity is mediated through Sp 1 and is negatively regulated by the MAPK signaling pathway[J]. Cell Signal, 2005, 17 (7): 1572-1577.
-
1林双（译）.曲格列酮可诱发实验动物发生结肠肿瘤[J].中华医学信息导报,2005,20(16):7-7.
-
2王丽,柳雅玲,李亚鲁.乳腺导管内癌、浸润性导管癌中PPAR-γ和COX-2的联合检测及临床意义[J].中国妇幼保健,2015,30(14):2264-2267. 被引量：5
-
3欧阳靖霖,张琍.噻唑烷二酮类药物抗肿瘤机制研究进展[J].癌症进展,2015,13(5):494-498. 被引量：2
-
4刘晓云,刘超.噻唑烷二酮类药物的抗肿瘤作用[J].国际内科学杂志,2009,36(6):331-336. 被引量：4
-
5陈富勇,王守森,王水良,王如密.曲格列酮减少CyclinD1的表达抑制体外培养GH3细胞增殖的实验研究[J].中华神经医学杂志,2008,7(11):1114-1119.
-
6尤文,张杰.噻唑烷二酮类药物抑制肿瘤细胞作用研究进展[J].上海医药,2013,34(1):49-52. 被引量：1
-
7戴克,王守森,王如密.噻唑烷二酮类药物治疗垂体腺瘤的研究进展[J].中国微侵袭神经外科杂志,2005,10(12):571-573.
-
8彭韦霞,文芳.PPAR-γ在甲状腺癌中的研究[J].医学综述,2006,12(20):1240-1242. 被引量：1
-
9陈富勇,王守森,王水良,王如密.曲格列酮体外抑制大鼠垂体腺瘤GH3细胞增殖[J].第二军医大学学报,2008,29(9):1052-1055. 被引量：1
-
10吴良洪,程南生,熊先泽,魏大鹏.PPAR-γ配体罗格列酮对胆管癌细胞增殖抑制作用的实验研究[J].四川大学学报（医学版）,2007,38(2):295-297. 被引量：1
