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骨髓间质干细胞移植治疗脊髓损伤的研究进展 被引量：1

Advances in the treatment of spinal cord injury by bone marrow-derived mesenchymal stem cell transplantation
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摘要 脊髓损伤（spinal cord injury，SCD临床常见，致瘫率高．其治疗一直是医学界的一项难题。SCI后，由于中枢神经系统没有能提供断裂轴突有效再生的微环境而使SCI不能痊愈，给伤者留下严重的躯体功能障碍。神经元和神经胶质细胞丧失是SCI后脊髓功能永久性障碍的主要原因。因为中枢神经系统自我修复能力有限．故而目前最有效的方法是通过细胞移植来替代缺失的神经细胞。
作者 白月双 余勤 盛丽先
机构地区 浙江中医药大学第一临床医学院 浙江中医药大学生物工程学院 浙江中医药大学第一附属医院儿科
出处 《中华神经医学杂志》 CAS CSCD 2008年第2期203-205,共3页 Chinese Journal of Neuromedicine
基金 浙江省科技厅科研基金（2004C33014） 浙江省中医药科研基金（2004C008）
关键词 间质干细胞 细胞移植 脊髓损伤 Mesenchymal stem cells Cell transplantation Spinal cord injury
分类号 R651.2 [医药卫生—外科学]
  • 相关文献

参考文献22

  • 1Garbossa D, Fontanella M, Fronda C, et al. New strategies for repairing the injured spinal cord: the role of stem cells[J]. Neurol Res, 2006, 28(5): 500-504.
  • 2Wexler SA, Donaldson C, Denning-Kendall P, et al. Adult bone marrow is a rich source of humane mesenchymal stem cells but umbilical cord and mobilized adult blood arc not[J]. Br J Haematol, 2003, 121(2): 368-374.
  • 3余勤,连俊兰,王艳,郭莹,万海同.大鼠骨髓间质干细胞体外培养扩增及生物学特性研究[J].浙江中医药大学学报,2006,30(2):189-192. 被引量：18
  • 4Colter DC, Class R, Digirolamo CM, et al. Rapid expansion of recycling stem cells in culture of plastic adherent cells from human bone marrow[J]. Proc Natl Acad Sci USA, 2000, 97(7): 3213-3218.
  • 5余勤,罗依,鄂艳,盛丽先,董勤,丁伟,郭莹.丹参素定向诱导骨髓间质干细胞分化为神经元样细胞的研究[J].中国中西医结合杂志,2005,25(1):49-53. 被引量：34
  • 6Matsubara T, Tsutsumi S, Pan H, et al. A new technique to expand humane mesenchymal stem cells using basement membrane extracellular matrix[J]. Biochem Biophys Res Commun, 2004, 313(3): 503-508.
  • 7Allen AR. Surgery of experimental lesions of spinal cord equivalent to crush injury of fracture dislocation of spinal column[J]. JAMA, 1911,57: 878-880.
  • 8Bavetta S, Hamlyn P J, Burnstock G, et al. Three facts of FK506 on dorsal column axons following spinal cord injury in adult rats: neuro protection and localre generation[J]. Exp Neurol, 1999, 158 (2): 382-393.
  • 9Sheng H, Wang H, Homi HM, et al. A no-laminectomy spinal cord compression injury model in mice[J]. J Neurotrauma, 2004, 21(5): 595-603.
  • 10Cameron T, Prado R, Watson BD, et al. Photochemically induced cystic lesion in the rat spinal cord, Behavior alandmorpho logical analysis[J]. Exp Neurol, 1990, 109(2): 214-223.

二级参考文献39

  • 1Woodbury D, Schwarz E J, Prockop DJ, et al. Adult rat and human bone marrow stromal cells differentiate into neurons. J Neur Sci Res 2000;61(4):364--370.
  • 2Guevas P, Carceller F, Dujovny M, et al. Peripheral nerve regeneration by bone marrow stromal cells. Neurol Res 2002 ;24( 7 ) : 634--638.
  • 3Kopen GC, Prockop DJ, Phinney DG. Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc Natl Acad Sci USA 1999;96(19) : 10711--10716.
  • 4Zhao LR, Duan WM, Reyes M, el al. Human bone marrow stem cells exhibit neural phenotypes and ameliorme neurological deficits after grafting into the ischemic brain of rms. Exp Neurol 2002;174(1):11--20.
  • 5Chen J, Li Y, Wang L, et al, Therapeutic benefil of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke 2001;32(4):1005--1011.
  • 6Jieli CHEN,Yi LI,Mark K,et al.Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat.Neuroscience Research,2003,73(6):778-786.
  • 7Y LI,J CHEN,L WANG,et al.Treatment of stroke in rat with intracarotid administration of marrow stromal cells.Neurology,2001,56(12):1666-1672.
  • 8Zea Longa EL,Weinstein PR,Carlson S,et al.Reversible middle cerebral artery occlusion without craniectomy in the rats.Stroke,1989,20(1):84-91.
  • 9Brailowsky S,Knight RT,Blook K,et al.Gamma-Aminobutyric acid-induced potentiation of cortical hemipegia.Brain Res,1986,362(2):322-330.
  • 10Pittenger MF,Mackay AM,Beck SC,et al.Multilineage potential of adult human mesenchymal stem cells.Science,1999,284(5411):143-147.

共引文献82

同被引文献19

  • 1李现铎,耿红全,朱哲,潘骏,谢华,陈方.孕中期羊水来源胎儿间充质干细胞的分离与培养及其生物学特性研究[J].中华医学杂志,2006,86(7):481-483. 被引量：14
  • 2余勤,连俊兰,王艳,郭莹,万海同.大鼠骨髓间质干细胞体外培养扩增及生物学特性研究[J].浙江中医药大学学报,2006,30(2):189-192. 被引量：18
  • 3王少云,黄河.骨髓基质干细胞移植治疗脊髓损伤进展[J].昆明医学院学报,2007,28(02B):86-90. 被引量：3
  • 4Kim HJ,Lee JH,Kim SH. Therapeutic effects of human mesenehymal stem cells on traumatic brain injury in rats:secretion of neurotrophic factors and inhibition of apoptosis[J].Journal of Neurotrauma,2010,(01):131-138.
  • 5Mahmood A,Lu D,Qu C. Treatment of traumatic brain injury with a combination therapy of marrow stromal cells and atorvastatin in rats[J].Neurosurgery,2007,(03):546-553.
  • 6Colter DC,Class R,Digirolamo CM. Rapid expansion of recycling stem cells in culture of plastic adherent cells from human bone marrow[J].Proceedings of the National Academy of Sciences(USA),2000,(07):3213-3218.doi:10.1073/pnas.070034097.
  • 7Dezaw a M,Kanno H,HoshionM. Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation[J].Journal of Clinical Investigation,2004.1701-1710.
  • 8Parr AM,Tator CH,Keating A. Bone marrow-derived mesenchymal Stromal cells for the repair of central nervous system injury[J].Bone Marrow Transplantation,2007,(07):609-619.doi:10.1038/sj.bmt.1705757.
  • 9Dasari VR,Spomar DC,Gady C. Mesenchymal stem cells from rat bone marrow downregulate caspase-3-mediated aoptotic pathway after spinal cord injury in rats[J].Newrochem Res,2007,(12):2080-2093.
  • 10Hill WD,Hess DC,Martin-Studdard A. SDF-1(CX-CL12)is upregulated in the ischemic penumbra.following stroke with bone marrow cell homly to injury[J].Nephron Experimental Neurology,2004,(01):84-96.

引证文献1

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中华神经医学杂志
2008年 第2期

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