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3-磷酸甘油醛脱氢酶与神经变性疾病 被引量：3

Glyceraldehyde-3-phosphate dehydrogenase and neurodegenerative diseases
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摘要 3-磷酸甘油醛脱氢酶（glyceraldehyde-3-phosphate dehydrogenase，GAPDH）是糖酵解中的一个关键酶，它催化3-磷酸甘油醛脱氢氧化成为1，3-二磷酸甘油酸，并最终将能量转移给ADP生成ATP。GAPDH一直以来都被认为是一个广泛存在的蛋白，除了糖酵解作用之外没有其它重要的生理功能。GAPDH基因也通常被认为是一个管家基因，作为研究其他基因构成、
作者 黄金莎 王涛
机构地区 华中科技大学同济医学院附属协和医院神经科
出处 《中华神经医学杂志》 CAS CSCD 2008年第2期206-208,共3页 Chinese Journal of Neuromedicine
关键词 3-磷酸甘油醛脱氢酶 神经变性疾病 细胞凋亡 Glyceraldehyde-3-phosphate dehydrogenase Neurodegenerative disease Apoptosis
分类号 R741 [医药卫生—神经病学与精神病学]
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参考文献19

  • 1Sirover MA, New insights into an old protein: the functional diversity of mammalian glyceraldehyde-3-phosphate dehydrogenase[J]. Biochim Biophys Acta, 1999, 1432(2): 159-184.
  • 2Sirover MA. New nuclear functions of the glycolytic protein, glyceraldehyde-3-phosphate dehydrogenase, in mammalian cells[J]. J Cell Biochem, 2005, 95(1): 45-52.
  • 3Verdier Y, Huszar E, Penke B, et al. Identification of synaptic plasma membrane proteins co-precipitated with fibrillar beta-amyloid peptide[J]. J Neurochem, 2005, 94(3): 617-628.
  • 4Tsuchiya K, Tajima H, Yamada M, et al. Disclosure of a pro-apoptotic glyceraldehyde- 3 -phosphate dehydrogenase promoter: anti-dementia drugs depress its activation in apoptosis[J]. Life Sci, 2004, 74(26): 3245-3258.
  • 5Li Y, Nowotny P, Holmans P, et al. Association of late-onset Alzheimer' s disease with genetic variation in multiple members of the GAPD gene family[J]. Proc Natl Acad Sci USA, 2004, 101(44): 15688-15693.
  • 6Lin PI, Martin ER, Bronson PG, et al. Exploring the association of glyceraldehyde-3-phosphate dehydrogenase gene and Alzheimer disease[J]. Neurology, 2006, 67(0: 64-68.
  • 7Tatton NA. Increased caspase 3 and Bax immunoreactivity accompany nuclear GAPDH translocation and neuronal apoptosis in Parkinson's disease[J]. Exp Neurol, 2000, 166(1): 29-43.
  • 8Mazzola JL, Sirover MA. Alteration ofintracellular structure and function of glyceraldehyde-3-phosphate dehydrogenase: a common phenotype of neurodegenerative disorders? [J]. Neurotoxicology, 2002, 23(4-5): 603-609.
  • 9Tsuchiya K, Tajima H, Kuwae T, et al. Pro-apoptotic protein glyceraldehyde-3-phosphate dehydrogenase promotes the formation of Lewybody-likeinclusions [J]. Eur J Neurosci, 2005, 21 (2): 317-326.
  • 10Fukuhara Y, Takeshima T, Kashiwaya Y, et al. GAPDH knockdown rescues mesencephalic dopaminergic neurons from MPP^+ -induced apoptosis[J]. Neuroreport, 2001, 12(9): 2049-2052.

同被引文献56

  • 1李文峰,刘晓林,杨林楠,武尔维,徐文博.基于Web的莲藕智能选种与诊断决策系统[J].云南大学学报（自然科学版）,2011,33(S2):279-283. 被引量：3
  • 2张克忠,蒋雨平.α-synuclein与帕金森病[J].中国临床神经科学,2004,12(4):434-437. 被引量：4
  • 3Colell A,Green DR,Ricci JE.Novel roles for GAPDH in cell death and carcinogenesis[J].Cell Death Differ,2009,16:1573-1581.
  • 4Tristan C,Shahani N,Sedlak TW,et al.The diverse functions of GAPDH:views from different subcellular compartments[J].Cell Signal,2011,23:317-323.
  • 5Hara MR,Cascio MB,Sawa A.GAPDH as a sensor of NO stress[J].Biochim Biophys Acta,2006,1762:502-509.
  • 6Patterson RL,van Rossum DB,Kaplin AI,et al.Inositol 1,4,5-trisphosphate receptor/GAPDH complex augments Ca2+ release via locally derived NADH[J].Proc Natl Acad Sci U S A,2005,102:1357-1359.
  • 7Tsuchiya K,Tajima H.Kuwae T,et al.Pro-apoptotic protein glyceraldehyde-3-phosphate dehydrogenase promotes the formation of Lewy body-like inclusions[J].Eur J Neurosci,2005,21:317-326.
  • 8Butterfield DA,Hardas SS,Lange ML.Oxidatively modified glyc-eraldehyde-3-phosphate dehydrogenase(GAPDH)and Alzheimer'sdisease:many pathways to neurodegeneration[J].J Alzheimers Dis,2010,20:369-393.
  • 9Piechaczyk M,Blanchard JM,Riaad-El Sabouty S,et al.Unusual abundance of vertebrate 3-phosphate dehydrogenase pseudogenes[J].Nature,1984,312:469-471.
  • 10Olah J,Tokesi N,Vincze O,et al.Interaction of TPPP/p25 pro-tein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies[J].FEBS Lett,2006,580:5807-5814.

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中华神经医学杂志
2008年 第2期

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