摘要
控制反应物摩尔比、反应温度和反应时间,1,3,5-三甲氧基苯与对位取代苯甲酰氯发生Friedel-Crafts反应,选择性地合成了2-羟基-4,6-二甲氧基-4-R-二苯甲酮和3-(4″-R-苯甲酰基)-2-羟基-4,6-二甲氧基-4-R-二苯甲酮。反应条件温和,产率较高。化合物的结构都经元素分析、1HNMR和IR确定。
The Friedel Crafts reaction of 1,3,5 trimethoxybenzene with p substituted benzoyl chlorides can be used to synthesize selectively 2 hydroxy 4,6 dimethoxy 4 R benzophenones and 3 (4″ R benzoyl) 2 hydroxyl 4,6 dimethoxy 4 R benzophenones by controlling molar ratio of reactants, reaction time and temperature. Synthetic condition was mild and the yields were 37%~81%. The structures of all compounds were identified by elemental analysis, 1H NMR and IR.
出处
《合成化学》
CAS
CSCD
1997年第1期54-56,共3页
Chinese Journal of Synthetic Chemistry
关键词
取代邻羟基
二苯甲酮
合成
F-C反应
Substituted o Hydroxybenzophenones, Synthesis, 1,3,5 Trimethoxybenzene, p Substituted benzoyl chlorids, Friedel Crafts reaction