钯单膦配体络合物催化氯苄双羰基化反应研究

Double carbonylation of C 6H 5CH 2Cl catalyzed by palladium complexes

利用４种新型单膦配体与钯形成的络合物作为均相催化剂，研究了氯苄双羰基化生成苯基丙酮酸甲酯的催化反应；考察了反应温度、ＣＯ压力和Ｐｄ／ＰｈＣＨ２Ｃｌ（ｍｏｌ比，下同）的影响。结果表明，当反应温度为１００℃，ＣＯ压力为６．０ＭＰａ，Ｐｄ／ＰｈＣＨ２Ｃｌ为０．８时，络合物（Ⅰ）作为氯苄双羰基化反应的均相催化剂，生成苯基丙酮酸甲酯的产率和选择性分别可达９５％和９３％。

Yan shiyan (State Key Laboratory of OXO Synthesis and Selective Oxidation,Lanzhou Institute of Chemical Physics,Lanzhou 730000) The double carbonylation reaction of C 6H 5CH 2Cl has been studied using Pd complexes with four new monophosphine ligands as homogeneous catalyst.The effect of reaction temperatures,CO pressure,and Pd/PhCH 2Cl mole ratio on the yield and selectivity of the reaction product C 6H 5CH 2COCOOCH 3 is also discussed.Using complex(Ⅰ)as a homogeneous catalyst for double carbonylation of C 6H 5CH 2Cl, the yield and selectivity of the product C 6H 5CH 2COCOOCH 3 are 95% and 93% respectively at 100℃,CO pressure 6.0 MPa and Pd/PhCH 2Cl mole ratio 0.8.