丙泊酚治疗难治性癫痫持续状态的临床研究进展

Progress of propofol in the clinical treatment of refractory status epilepticus

难治性癫痫持续状态是一种严重的内科急症,具有很高的死亡率,临床治疗非常棘手。近年来,越来越多的临床研究和病例报告显示,丙泊酚(又名异丙酚)对难治性癫痫持续状态有较好的疗效,但治疗过程中也有发生严重并发症的危险。本文综述了近年来丙泊酚治疗难治性癫痫持续状态的临床研究进展及其可能的作用机制。

Refractory status epilepticus, a severe emergency with high mortality, is hard to be dealed with in clinics. Recently, more and more clinical researches and case reports showed that propofol could produce significantly anticonvulsant effect on refractory status epilepticus even though it has possibly severe complication in the course of treatment. This paper reviews the current progress of propofol in the clinical treatment of refractory status epilepticus and its possible mechanisms.