35岁以下乳腺癌C-erbB-2和p53癌基因与雌孕激素受体表达关系的研究

Relation between expression of C-erbB-2,p53 genes and estrogen,progesterone receptors in breast carcinoma of patients under 35 years of age

目的探讨35岁以下乳腺癌C-erbB-2、p53癌基因与雌激素(ER)、孕激素(PR)受体表达之间关系。方法应用免疫组化对100例35岁以下乳腺癌的C-erbB-2、p53、ER、PR表达进行检测研究。结果C-erbB-2、p53、ER、PR阳性表达率分别为78.0%、67.6%、54.0%和54.0%;C-erbB-2、p53阳性表达与临床分期、肿瘤大小、淋巴结转移及ER状态无相关性。结论35岁以下乳腺癌C-erbB-2、p53癌基因具有高表达,增加了转移潜能及侵袭性可能。

Objective To investigate the relation between the expression of C-erbB-2, p53 and estrogen receptor（ER）, progesterone receptor（PR） Of breast carcinoma in patients under 35 years of age. Methods The expression of C-erbB-2,p53,ER and PR was detected by immunohistoehemieal technique in 100 cases of breast carcinoma under 35 years of age. Results The poistive expression rates of C-erbB-2, p53, ER,PR were 78.0% ,67.6% ,54.0% ,54.0% ,respectively. There was no correlation between the poisrive expression of C-erbB-2 ,p53 with clinical stages ,tumor size and lymphatic metastasis. Conclusion The expression rates of C-erbB-2 and p53 in breast carcinoma of patients under 35 years of age are high. It may increase metastasis potential and invasion possibility.