摘要
目的:观察扩张型心肌病(DCM)患者外周血中可溶性细胞间黏附分子-1(sICAM-1)的水平及与血管功能和心功能的关系。方法:DCM患者65例,正常对照组49例。用酶联免疫吸附法测定2组血清中sICAM-1的水平;用无创动脉功能测定仪测定大动脉弹性指数(C1)和小动脉弹性指数(C2)。用NYHA分级评价心功能。结果:①DCM组外周血sICAM-1的水平显著高于正常对照组,而DCM组C2显著低于正常对照组,2组间C1差异无统计学意义;②血清sICAM-1与C2呈负相关。sICAM-1是影响C2的重要因素;③随着心功能下降,血清中sICAM-1的水平逐渐升高,两者呈等级相关。结论:DCM患者心功能和血管内皮功能下降与sICAM-1升高有关。
Objective: To investigate the relationship between serum soluble intercellular adhesion molecule-1 (sICAM-1) and artery compliance as well as cardiac function in patients with dilated cardiomyopathy (DCM). Method:Sixty-five patients with DCM and forty-nine healthy volunteers were enrolled in the study. Serum concentration of sICAM-1 was analyzed by quantitative enzyme-llnked immunosorbent assay (ELISA). The severity of heart failure was assessed by the New York Heart Association (NYHA)-classification. Both large artery compliance (C1) and small artery compliance (C2) were measured. Result: (1)sICAM-1 levels were significantly higher in patients with DCM than in controls. C2 was significantly lower in DCM patients than controls, whereas C1 remained unchanged in comparison with the controls. (2)sICAM-1 was negatively correlated with C2 in patients with DCM. sICAM-1 was the important risk factor for C2. (3)sICAM-1 levels were negatively associated with the heart failure and there was rank correlation between sICAM-1 and heart failure. Conclusion:The increased sICAM-1 was related to the decreased C2 and the cardiac function in patients with DCM.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2008年第1期14-17,共4页
Journal of Clinical Cardiology
关键词
心肌病
扩张型
细胞黏附分子1
心功能
Dilated cardiomyopathy
Cell adhesion molecules
Cardiac function