2型糖尿病患者总同型半胱氨酸水平影响因素分析

Multiplicity of plasma concentration of total homocysteine in patients with type 2 diabetes mellitus

目的:探讨2型糖尿病(DM)患者总同型半胱氨酸(t Hcy)水平的影响因素。方法:随机选择308例患者,根据血糖分组:正常血糖组(Ⅰ组)109例,糖耐量减低组(Ⅱ组)75例,2型DM组(Ⅲ组)124例。所有患者均测量t Hcy、身高、体重、腰围、血压、血脂、血糖、胰岛素及肌酐水平。结果:Ⅲ组和Ⅱ组的t Hcy高于Ⅰ组,差异有统计学意义(P<0.05)。多元线性回归分析表明:t Hcy与IR、肌酐呈正相关(β=0.158,P=0.022;β=0.163,P=0.029);男性t Hcy水平高于女性(β=-0.164,P=0.03)。结论:性别、肌酐水平、IR是同型半胱氨酸水平的影响因素。

Objective：To investigate the association between insulin resistance （IR） and total homocysteinemia （tHcy） in patients with type 2 diabetes mellitus （DM）. Method： Three hundred and eight patients were selected randomly to divide into 3 groups, including normal group （Ⅰ group, 109 cases）, impaired glucose tolerance group （Ⅱ group, 75 cases）, type 2 DM group （Ⅲ group, 124 cases）. All of them were underwent detections involved in plasma tHcy, height, weight, waistline, blood pressure, lipids, blood glucose, insulin, serum creatinine. Result： The concentrations of tHcy were increased significantly in Ⅲ and Ⅱ groups, compared with Ⅰ group（P〈0.05）. Multiple linear regression analysis showed that tHcy was positively correlated with IR and serum creatinine（β=0. 158,P=0. 022;β=0. 163,P=0. 029）. The tHcy was influenced by gender because male had more risk of tHcy （β=-0.164, P= 0. 03）. Conclusion： The level of serum creatinine and gender were influencial facfor of hHcy, and hHcy seemed to be associated with IR.