不同阶段血管性认知功能障碍患者事件相关电位P300的特点

The Features of Event-Related Potential P300 in Patients with Different Stages of Vascular Cognitive Impairment

目的:探讨不同阶段血管性认知功能障碍(VCI)患者的听觉ERP-P300特点,以为其早期诊断提供客观依据。方法:根据VCI诊断标准选取血管性痴呆(VaD)、无痴呆的血管认知功能障碍(VCIND)患者各50例,并以认知功能正常的脑血管病患者50例为对照组,分别对其进行听觉ERP-P300检测。结果:(1)与对照组相比VCIND组P300潜伏期、N200-P300波间期延长,P300波幅减低;VaD组N200、P300潜伏期,P200-N200、N200-P300波间期明显延长,P300波幅减低,差异有统计学意义。(2)所有患者N200、P300潜伏期与性别无关,与MMSE分数呈负相关,P300潜伏期与年龄正相关。结论:VCIND组患者的ERP-P300特点为P300潜伏期、N200-P300波间期延长,P300波幅减低;VaD组除上述特点外,N200潜伏期、P200-N200波间期延长。ERP-P300对VCI有一定的早期诊断价值。

Objective： To investigate the features of ERP-P300 in different stages of VCI and provide objective foundations for the early diagnosis of VCI. Methods： Fifty patients with VaD and 50 patients with VCIND were selected according to diagnostic standard of VCI, and ischemic cerebmvascular disease patients with normal cognition as a control group. Auditory ERP-P300 were studied separately. Results： （ 1 ）Compared with VCIND and control group, the latencies of N200, P300 and intervals of P200-N200, N200-P300 were obviously prolonged in VaD group. Compared with the control group,the latency of P300 and interval of N200-P300 in VCIND group were prolonged,the differences had statistical significance （P 〈 0.01 ）. （2）In all patients the latencies of N200 and P300 had no correlation with sex, but had a negative correlation with a cognitixe assessment-MMSE score, the latency of P300 had a positive correlation with age. Conclusion： The features of ERP-P300 in VCIND are prolonged latency of P300 and the intervals of N200-P300, and reduced amplitude of P300. In VaD the latency of N200 and the intervals of P200-N200 are prolonged excluded the character of VCIND. ERP- P300 has a diagnosis value for VCI patients.