2型糖尿病患者血清超敏C反应蛋白与血脂、血糖检测的应用

Application of high-sensitive C-reactive protein and serum lipids and plasma glucose in type 2 diabetes mellitus

目的探讨2型糖尿病（T2DM）患者血清超敏C反应蛋白（hs-CRP）与血脂、血糖的相关性及临床应用。方法检测正常对照（NC）组、T2DM组空腹状态下血清hs-CRP、血脂、血糖、血清胰岛素水平和餐后2h血糖及血清胰岛素水平。结果NC组血清hs-CaP[0．40（0．21～1．67）mg／L]显著低于T2DM组[3．6（1．83～8．94）mg／L]（P〈0．01）。T2DM组血清hs-CRP与甘油三脂（TG）、载脂蛋白B（ApoB）、空腹血糖（FPG）、餐后2h血糖（PPG）、空腹胰岛素（FINS）、餐后2h胰岛素（PSI）呈正相关（P〈0．05或P〈0．01），与高密度脂蛋白（HDL）呈负相关（P〈0．01）。结论T2DM患者血清hs-CRP水平显著升高，hs-CRP与TG、ApoB、FPG、PPG、FINS、PSI正相关，与HDL负相关。

Objective To discuss the application of serum highly sensitive C-reactive protein （hs-CRP） , lipids and plasma glucose detection and the correlations between them in type 2 diabetes mellitus （DM）. Methods The levels of serum hs-CRP, lipids, fasting plasma glucose （ FPG）, postprandial plasma glucose （PPG） , fasting serum insulin（FINS）, and postprandial serum insulin （PSI） were measured in type 2 diabetic patients and normal cases （ NC ）. Results Compared with NC group [ hs-CRP 0. 40 （0. 21 - 1.67 ）mg/L], the serum hs-CRP was significantly increased in type 2 DM group[ 3.6（ 1.82 -8.94）mg/L]. The serum hs-CRP level was negatively correlated with high density lipopratein cholesterol （HDL-C）（ P 〈0. 05 ）, and positively correleted with triglyceride（TG）, apoliporotein B （ ApoB）, FPG, PPG, FINS and PSI （ P 〈 0. 05 or P 〈 0. 01 ）. Conclusion Serum hs-CRP level increases in type 2 DM groups, and is positively correlated with TG, ApoB, FPG, PPG, FINS, PSI, while is negatively correlated with HDL-C.