雌激素对高糖环境兔血管内皮功能影响的研究

Effects of estrin on the function of blood vessel endothelium in high concentration of glucose

高糖组及高糖+17β-雌二醇(E2)组分别孵育腹主动脉环6小时,结果显示高糖引起血管内皮舒张反应减弱,环磷酸鸟苷(cGMP)含量和一氧化氮合酶(NOS)活性降低(P<0.001);而E2使高糖作用下内皮舒张反应增强,cGMP含量和NOS活性增加(P<0.05)。

The abdominal aorta rings were treated with high glucose and with various concentrations of estradiol for 6 hours. We found that at the group of higher glucose the endothelium-induced vascular relaxation was weaken, cGMP production and NOS activity were significantly decreased（P〈0. 001）. Whereas at the group of high glucose plus estradiol,compared with the group of only high glucose, the vascular relaxation,cGMP level and NOS activity were increased（P〈0.05）.