单纯IGT和单纯IFG个体高敏C反应蛋白水平的差异及相关因素分析

Analysis of the different levels of serum high sensitivity C-reactive protein and its related factors in subjects with isolated IGT or IFG

目的比较正常空腹血糖/正常糖耐量(NFG/NGT)、空腹血糖受损(IFG)、糖耐量减低(IGT)及IFG/IGT个体的血清高敏C反应蛋白(hsC-RP)水平的差异,并对其相关因素进行分析。方法将443名39～65岁非糖尿病(DM)个体根据OGTT分为以下4组:NFG/NGT、单纯IFG、单纯IGT和IFG/IGT组。比较各组间血清hsC-RP的差异,并对与之相关的变量进行统计学分析。结果IGT组比IFG组hsC-RP水平明显升高(P<0.05),IFG组与NFG/NGT组以及IGT组与IFG/IGT组间的hsC-RP水平没有明显统计学差异(P>0.05)。多元逐步回归分析显示,BMI和胰岛素抵抗指数是hsC-RP的独立预告因子。结论IGT比IFG个体的血清hsC-RP水平明显升高,hsC-RP与胰岛素抵抗和代谢综合征的多种组分相关。

Objective To compare the levels of serum high sensitivity C-reactive protein（hsC-RP） among subjects with normal fasting glucose plus normal glucose tolerance（NFG/NGT）, IFG, IGT and IFG plus IGT,and to analyze the related risk factors. Methods 443 nondiabetic subjects aged 39-65 years were seperated into four groups： NFG plus NGT, IFG, IGT and IFG plus IGT. The serum hsC-RP levels and related factors were analyzed. Results Compared with IFG subjects,IGT subjects had higher hsC- RP levels. No differences in hsC-RP levels were found between NFG plus NGT group and IFG group, as well as between IGT group and IFG plus IGT group. Stepwise multiple regression showed that BMI and HOMA-IR were independent predictors of hsC-RP. Conclusions IGT subjects have significantly higher serum hsC-RP level than IFG subjetcts. The serum level of hsC-RP is associated with insulin resistance and the components numbers of metabolic syndrome.