我国维吾尔族成人代谢综合征腰围适宜切点研究

The appropriate cut-off point of waist circumference for identifying metabolic syndrome in Chinese Uygur adults

目的研究我国维吾尔族成人代谢综合征(MS)诊断中腰围的适宜切点。方法以乌鲁木齐市和喀什地区2526例25～90岁维吾尔族成人为研究对象,以国际糖尿病联盟(IDF)MS全球共识诊断标准为基础,分析维吾尔族男女不同腰围水平与MS其他组分聚集的关系,检出至少两个组分存在时假阳性率和假阴性率均较低的腰围界限,作为诊断维吾尔族成人MS腰围切点,并以此计算不同年龄组MS的检出率及成分组合特点。结果随腰围增大,MS组分聚集的OR值显著增高。在我们所划分的切点中,当男性腰围≥93cm、女性腰围≥89cm时,ROC曲线距离最短。以此腰围切点计算维吾尔族成人的MS检出率,男性为26.0%,女性为27.7%。结论建议维吾尔族以男性腰围≥93cm、女性腰围≥89cm为切点,结合IDF诊断标准中其他组分定义,作为维吾尔族成人MS的临床检出标准。以上结果有待在更大样本量的维吾尔族人群中进一步验证。

Objective To analyze the appropriate cut-off point of waist circumference for identifying metabolic syndrome（MS） in Chinese Uygur adults. Methods Based on the IDF consensus worldwide definition of metabolic syndrome（2005） ,2526 Uygur adults aged 25-90 years from Urumqi city and Kashgar region were enrolled to analyze the ORs of the clustering of MS components at different sizes of waist circumference. The sensitivity, specificity and distance in ROC curve by different cut-off points of waist circumference for identifying two components of MS were estimated to find the cut-off points for men and women in Uygur with the shortest distance of ROC curve. Results The ORs of the clustering of MS components were increased significantly with the sizes of waist circumference. The waist circumference ≥93 cm for men, ≥89 cm for women） corresponded to. the shortest distance of ROC curve, namely, at these cut-off points, the rates of false positive and false negative for identifying MS were minimum. The prevalence of MS was 26.0% and 27.7% in men and women respectively. Condusions The waist circumferences≥93 cm for men, and≥89 cm for women are the appropriate cut-off points for identifying MS in Uygur. This recommendation needs further confirmation in a larger sample group of Uygurs.