摘要
目的:探讨低增生性骨髓增生异常综合征(Hypo-MDS)的临床特点。方法:根据有关诊断标准,从60例低增生性骨髓增生异常综合征(Hypo-MDS)患者初发病时的临床表现、血象、骨髓象、骨髓病理学和细胞遗传学等方面回顾性分析Hypo-MDS的临床特点,并与同期Normo/Hyper-MDS进行比较分析。结果:共诊治Hypo-MDS60例,男∶女=1.5∶1,血红蛋白(47.15±15.63g/L),血小板(25.57±18.84)×109/L,中性粒细胞(0.81±0.58)×109/L。行染色体检查的39例中,染色体异常12例,根据IPSS,39例低危组有0例,中危组-131例,中危组-27例,高危组1例。结论:Hypo-MDS是MDS的一种特殊类型,不同于Normo/Hyper-MDS。
Objedtive:To discuss the clinical characteristic of the hypoplastic myelodysplastic syndrome (Hypo-MDS). Method: In accordance with relevant diagnostic criterions , we carry out clinical comparative analysis focusing on Hypo-MDS, compared with normo/hyper-cellular myelodysplastic syndrome (Normo/Hyper-MDS), from multiple angles, such as clinical course, blood routine examination, bone marrow cytology, bone marrow biopsy, cytogenetics, prognosis ect. Result: In the First Hospital of Jilin University Jili, from 2000 to 2005, there were 60 patients with Hypo-MDS, male predominance (M/F= 1.5: 1). Mean hemoglobin was (47.15±15.63) g/L, mean platelet and neutrofil counts were (25.57± 18.84) ×10^9/L and(0. 81±0.58) ×10^9/L, respectively, and 12 patients had chromosome aberration. Acording to IPSS, there are 31 patients in moderate group- Ⅰ , 7 ones in moderate group-Ⅱ , only one in severe group, none in low group. Conclusion: Hypo -MDS appears to be a separate clinicopathologic variant of MDS.
出处
《临床血液学杂志》
CAS
2008年第1期32-34,共3页
Journal of Clinical Hematology