60例低增生性骨髓增生异常综合征的临床分析

Clinical analyse of 60 cases of hypoplastic myelodysplastic syndrome

目的:探讨低增生性骨髓增生异常综合征(Hypo-MDS)的临床特点。方法:根据有关诊断标准,从60例低增生性骨髓增生异常综合征(Hypo-MDS)患者初发病时的临床表现、血象、骨髓象、骨髓病理学和细胞遗传学等方面回顾性分析Hypo-MDS的临床特点,并与同期Normo/Hyper-MDS进行比较分析。结果:共诊治Hypo-MDS60例,男∶女=1.5∶1,血红蛋白(47.15±15.63g/L),血小板(25.57±18.84)×109/L,中性粒细胞(0.81±0.58)×109/L。行染色体检查的39例中,染色体异常12例,根据IPSS,39例低危组有0例,中危组-131例,中危组-27例,高危组1例。结论:Hypo-MDS是MDS的一种特殊类型,不同于Normo/Hyper-MDS。

Objedtive：To discuss the clinical characteristic of the hypoplastic myelodysplastic syndrome （Hypo-MDS）. Method： In accordance with relevant diagnostic criterions , we carry out clinical comparative analysis focusing on Hypo-MDS, compared with normo/hyper-cellular myelodysplastic syndrome （Normo/Hyper-MDS）, from multiple angles, such as clinical course, blood routine examination, bone marrow cytology, bone marrow biopsy, cytogenetics, prognosis ect. Result： In the First Hospital of Jilin University Jili, from 2000 to 2005, there were 60 patients with Hypo-MDS, male predominance （M/F= 1.5： 1）. Mean hemoglobin was （47.15±15.63） g/L, mean platelet and neutrofil counts were （25.57± 18.84） ×10^9/L and（0. 81±0.58） ×10^9/L, respectively, and 12 patients had chromosome aberration. Acording to IPSS, there are 31 patients in moderate group- Ⅰ , 7 ones in moderate group-Ⅱ , only one in severe group, none in low group. Conclusion： Hypo -MDS appears to be a separate clinicopathologic variant of MDS.