摘要
目的:研究抗肿瘤药与消化道恶性肿瘤化疗患者感染发生风险的关系。方法:收集符合条件的消化道肿瘤化疗患者2384例,用Logistic回归分析不同种类化疗药物等因素对患者发生感染的风险性的相关性。结果:年龄、住院天数、费别、烷化剂、金属络合物、其他抗肿瘤药的回归系数分别为0.010,0.147,-0.361,-.930,- 0.390,-1.306。结论:年龄和住院天数都对感染发生产生正相关作用,参加医保可以降低感染的发生风险,抗肿瘤抗生素、植物来源抗肿瘤药物、抗代谢抗肿瘤药物比金属络合物抗肿瘤药物、烷化剂和其他类抗肿瘤药物在化疗期间具有较高的感染发生风险比。
Objective： To analyze the infectious ODDS risks of anticancer plant alkaloids and other anticancer drugs in GI cancer patients with chemotherapy regiments. Method： 2384 profiles of cancer patients agreeable with studying condition were collected. All the profiles were evaluated with different variants, and then these variants were analyzed with the logistic liner. Result： The line values of ages, days in hospital, insurances, alkylating agents, platinum antitumor compounds and other antitumor drugs were 0.010,0. 147,43.361,43. 930, 43.390, and -1. 306. Conclusion： The infection OR of the ages and days in hospital increased OR factors and the medical insurances decreased OR factors. Antitumor antibiotics, antimetabolites, plant alkaloids had their higher infectious risks than platinum antitumor compounds, alkylating agents and other antitumor drugs did in GI cancer patients with chemotherapy regiments.
出处
《药物流行病学杂志》
CAS
2008年第1期20-23,共4页
Chinese Journal of Pharmacoepidemiology
基金
青岛市卫生局立项课题(2004-WSJH001)
