代谢组学与中药现代化

Metabonomics and the Modernization of Traditional Chinese Medicine

近年来得以飞速发展的系统生物学,尤其是代谢组学的高通量、整体性的研究技术和研究思路,对中药方剂中活性物质的分析方法及其代谢产物的药代动力学分析提供了新思路和新方法。此外,代谢组学的研究思路,将为从现代科学的基础上解释中药的整体作用机制提供新方法;而代谢组学的研究成果,则可能为建立新型的基于代谢组学的中药药效评价的技术平台作出贡献。

The rapid development of systems biology and especially the advances in the high-throughput and comprehensive research technologies and research idea in metabonomics provide new strategies in the analysis of active components in the formula of traditional Chinese medicine （TCM） and pharmacokinetic analysis of their metabolites in vivo. Furthermore, the initiatives of metabonomics may pave a new way to explain the action mode of TCM in the light of modem sciences, while the metabonomic research achievements may contribute to the establishment of a new technique platform for evaluating the efficacy of the formula of TCM.