妊娠肝内胆汁淤积症患者血清中sVCAM-1及IL-6临床检测意义

Clinical Significance of Detection of Serum Soluble Vascular Cell Adhesion Molecule-l(sVCAM-1) and Interleukin-6(IL-6) of Patients with Intrahepatic Cholestasis of Pregnancy(ICP)

目的:探讨可溶性血管细胞粘附分子1(sVCAM-1)及白细胞介素-6(IL-6)在妊娠肝内胆汁淤积症(ICP)发病中的作用。方法:测定49例孕妇血清中sVCAM-1、IL-6水平,其中正常妊娠组15例,ICP组34例,包括轻度14例,重度20例。用酶联免疫吸附法测定sVCAM-1,用放射免疫法测定IL-6。结果:重度ICP患者血中sVCAM-1、IL-6水平均显著高于正常妊娠组(P<0.01),轻度ICP患者与正常妊娠组相比,虽有升高趋势,但无统计学意义,ICP组产后各项指标下降与正常妊娠组差异无统计学意义(P>0.05)。IL-6与sVCAM-1呈正相关(r=0.435,P<0.01)。结论:ICP患者sVCAM-1的异常表达可能是ICP发病机制的一个重要环节,IL-6可诱导sVCAM-1的表达。

Objective： To investigate circulating levels of soluble vascular cell adhesion molecule - 1 （ sVCAM - 1 ） and Interleukin-6 （IL-6） in the peripheral of intrahepatic cholestasis of pregnancy （ICP）, and to reveal the pathogenesis of ICP. Methods： Maternal serum sVCAM - 1 and IL- 6 were determined in 49 women including 15 cases of normal pregnant women （control group） and 34 cases of women with ICP（ICP group） including 14 cases of mild and 20 cases of severe ICP. sVCAM - 1 was measured by ELISA and IL - 6 by RIA. Results ： The levels of serum sVCAM - 1 and IL - 6 were significantly elevated in women with severe ICP compared with control subjects（ P 〈 0.01 ）. Compared with normal pregnancy group, the serum levels of VCAM - 1 and IL -6 showed the increasing trends but no significant difference were found. The decrease of serum levels of VCAM - l and IL - 6 in ICP group showed no significant difference compared with normal pregnancy group after delivery（P 〉0.05 ）, The IL -6 levels were positively correlated with sVCAM - 1 levels（ r = 0.435, P 〈 0.01 ）. Conclusion ： Abnormal expression of sVCAM - 1 may play an important role in the pathogenesis of ICP. IL - 6 can induce the expression of sVCAM - 1.