摘要
以20，60和180mg／kg体重剂量给大鼠喂食2，6－二叔丁基对甲酚（BHT），检测尿中AST、ALP、LDH和GGT等指标变化．结果表明：随染毒时间延长，各尿酶含量逐渐出现显著性用高，病理学检查发现高剂量组有1例间质性肾炎，提示BHT对肾功能可能产生有害作用．
Rats are administrated with BHT with doses of 0,20, 60 and 180mg/kg body weightconsecutively. After 1, 2, 3 and 4 months,biochemical indicators including AST,ALP,LDH and GGT etc. inurine were examined. The results showed that the contents of urinary enzymes increased graduallyand significantly as the time of intoxication elongated. A case of mesenchymal nephritis was foundin the highest dose group by pathological examination. It suggested that BHT may cause toxiceffect on renal function.
出处
《工业卫生与职业病》
CAS
CSCD
1997年第2期75-77,共3页
Industrial Health and Occupational Diseases
关键词
二叔丁基对甲酚
尿
生化指标
Butylated hydroxytoluene(BHT)
Urinary biochemical indicator
