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二硫化碳致大鼠行为改变的实验观察 被引量:2

EFFECTS OF CARBON DISULFIDE EXPOSURE ON THE BEHAVIOR OF RATS
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摘要 本实验选用自发活动、转棒测试、步下法及Morris水迷津,观察大鼠吸入不同浓度CS2(0,300,600,1200,2400mg/m3;4小时/日)2个月后的行为改变。结果提示,接触CS2对自发活动无明显影响,可使大鼠肌肉协调能力受损,学习记忆能力降低。 The effects of CS2 exposure were studied with four item neurobehavioral test battery, they werelocomotive activity test, rotarod test, step-down test and Morris water maze test. 7o SpragueDawely rats were randomly divided into 4 CS2 exposed groups and a control group. The rats exposed to 600 mg/m3 CS2(inh. ) exhibited impaired coordination function in the rotarod test. Theresults of step-down and Morris water maze, which re flect learning and memory functions, showedthat CS2 impaired the acquire and retention of memory in rats.
出处 《工业卫生与职业病》 CAS CSCD 1997年第3期139-142,共4页 Industrial Health and Occupational Diseases
关键词 二硫化碳 行为 毒理学 神经行为 Carbon disulfide Behavior
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