脂连素和C-反应蛋白在急性心肌梗死中的变化

Changes of serum levels of adiponectin and CRP in acute myocardial infarction

目的观察急性心肌梗死(AMI)发病后脂连素的动态改变及与C-反应蛋白(CRP)的关系,探讨其临床意义。方法选取27例AMI患者为研究对象,以ELISA法分别测定发病后24h内及第7天血清脂连素水平,并以15例冠心病作为对照组进行比较分析,两组同时测定血清CRP。结果AMI组血清脂连素在发病24h内明显低于冠心病组(P<0.001),随后逐渐上升,其值变化有统计学意义(P=0.007),同时AMI组血清CRP明显升高,与脂连素的变化呈负相关(r=-0.36,P=0.04)。结论血清脂连素水平下降与AMI发生密切相关,并在疾病早期恢复中可能起到抗炎及保护血管内皮细胞的作用。

Objective To investigate the dynamic changes of adiponectin and C-reactive protein（CRP）in acute myocardial infarction（AMI）and discuss their clinical meanings.Methods Serum concentrations of adiponectin were measured by ELISA in 27 patients with AMI（within 6～24 hours and on the 7th day of the onset）and 15 patients with coronary artery disease（CAD）respectively.Meanwhile,the levels of CRP were determined in both AMI and CAD groups.Results The values of adiponectin in AMI patients were significantly lower than those in CAD patients（P〈0.001）,in addition,the levels of adiponectin had dynamic changes.At the same time,the levels of CRP negatively correlated with adiponectin（r=-0.36,P=0.04）in AMI group.Conclusion The changes of adiponectin have closely relation to the incidence of the AMI and it may play an important role in anti-inflammation and protecting vascular endothelial cells.