镉对肾损害与尿酶活性的研究

Study on activity of urine enzyme in kidney damaged by cadmium

镉对肾早期损害的研究中，我们对４７名镉作业者采用尿中γ－谷氨酰转肽酶活性（γ－ＣＴ／ｇ·Ｃｒ），同时对尿镉、β２－微球蛋白（β２－ＭＧ）以及血中的γ－ＧＴ进行检测。结果表明：作业场所氧化镉在０．０５２～０．１２ｍｇ／ｍ３，平均工龄为６．６年的作业者，尿γ－ＧＴ／ｇ·Ｃｒ活性高于对照组（Ｐ＜０．０１）。其中超标者占２９．７％，而尿β２－ＭＧ超标者１２．７％。在尿γ－ＧＴ／ｇ·Ｃｒ异常的病例中有５０％尿β２－ＭＧ尚属正常。说明检测尿γ－ＧＴ／ｇ·Ｃｒ活性是镉对肾早期损害的敏感指标。

The urine γ GT,urine cadmium,β 2 microglobulin(β 2 MG)and the serum γ GT of 47 cases exposed to cadmium environment were measured.The results showed that those cases exposed to air concentration of cadmium oxide 0.052 and 0.12mg/m 3 and averaged working period 6.6 years had a higher urine γ GT than normal control( P <0.01).29.7% of them were higher than the normal standard,whereas only 12.7% of the urine β 2 MG were increased.50% of those cases with abnormal urine γ GT,showed a normal urine β 2 MG.It suggested that the level of urine γ GT would be a sensitive index for detecting early renal damage by cadmium.