调血益髓方和SSL方案治疗儿童慢性再生障碍性贫血的对照研究及其作用机理探讨

Comparative Study of Applying Tiaoxue Yisui Recipe and SSL Regimen in Treating Infantile Chronic Aplastic Anemia and Analysis of Its Therapeutical Mechanism

目的：为探讨中医药治疗儿童慢性再生障碍性贫血（ＣｈｒｏｎｉｃＡｐｌａｓｔｉｃＡｎｅｍｉａ，ＣＡＡ）的有效方法。方法：将７８例患者分为两组，用调血益髓方（观察组）治疗４８例，并与用ＳＳＬ方案（对照组）治疗的３０例进行比较。结果：观察组缓解率、总有效率分别为５２．０８％和８１．２５％，明显高于对照组（Ｐ均＜０．０５）；观察组治疗后骨髓造血细胞与非造血细胞比值、巨核细胞数值均高于对照组（Ｐ均＜０．０５）。结论：调血益髓方能有效地提高儿童ＣＡＡ患者的生存质量。其作用机理可能与促进造血干／祖细胞增殖、调节免疫有关。

To explore the effective method in treating infantile chronic aplastic anemia (ICAA) by using traditional Chinese medicine (TCM). Methods:seventy-eight cases of ICAA were observed,48 of them were treated with Tiaoxue Yisui recipe (treated group), 30 cases were treated with SSL regimen (control group). Results: The remission rate and total effective rate in treated group were 52. 08% and 81. 25% respectively,they were higher than those in control group(P<0. 05). After one year treatment the ratio of hemopoietic and non-hemopoietic cells in treated group was higher than that in control group (P<0. 05). The number of megakaryocyte in treated group was more than those in control group(P<0. 05). Conclusion:Tiaoxue Yisui recipe could improve the quality of the patient' s life. The therapeutical mechanism of the Tiaoxue Yisui recipe might promote the proliferation of hemopoietic stem cells and regulate the immune function.