山莨菪碱及地塞米松对兔多器官功能障碍时外周微循环的影响

Evaluation of Microcirculation in Rabbit with Multiple Organs Dysfunction Syndrome after Using Large Dose of Anisodaminum and Dexamathosonum

日本大耳兔行盲肠结扎加穿孔（ＣＬＰ）造成腹腔感染致多器官功能障碍的动物模型，然后应用瑞典ＰＥＲＩＭＥＤ公司的新型４００１双通道激光多普勒血流仪动态测定应用大剂量山莨菪碱及地塞米松时，免耳及大腿肌肉内微循环的变化。结果发现，用药后实验兔耳微循环的灌注量及微循环内红细胞等移动的微粒数量和兔大腿肌肉内微循环的灌注量及微循环内红细胞等移动的微粒数量均有显著升高。结果表明静脉注射大剂量山莨菪碱及地塞米松能明显改善兔在多器官功能障碍时微循环的灌注。

he microcirculation of rabbits with multiple organs dysfunction syndrome(MODS) after using large dose of anisodaminum and dexamathosonum were observed. First, the methods of cecum ligation and perfuration to create the model of MODS were used, then used Perifix 4001 Master Laser Doppler to evaluate the realtime microvascular perfusion after using large dose of anisodaminum and dexamathosonum. The results showed that after using the drug, the microvascular perfusion in leg muscule and ear were significant increased(P<0.01) both in health group and MODS group. It is suggested that the large dose of anisodaminum and dexamathosonum can improve the microcirculation in MODS. 