血清CA-50含量对消化系肿瘤的诊断价值

Diagnostic value of serum CA 50 in digestive neoplasms

目的评价血清ＣＡ＿５０对消化系肿瘤的诊断价值．方法消化系肿瘤患者１７２例，其中肝癌５４例，胃癌４３例，大肠癌５７例，胰腺癌１８例；消化系良性疾病患者８８例，其中肝硬变３６例，胃良性病变（胃炎、胃溃疡）５２例；正常对照者６０例．全部受测对象均抽空腹静脉血，分离血清，－２０℃贮存备测．采用ＲＩＡ法测定血清ＣＡ５０含量．放免药盒由中国医学科学院肿瘤研究所提供，使用国产ＦＪ６３０型γ计数仪．数据均用ｘ±ｓ表示，以正常ｘ＋２ｓ作为上限计算阳性率．结果肝癌、胃癌、胰腺癌和大肠癌血清ＣＡ５０含量分别为２４０ｋＵ／Ｌ±２１８ｋＵ／Ｌ，１２１ｋＵ／Ｌ±１０６ｋＵ／Ｌ，１８２ｋＵ／Ｌ±１０７ｋＵ／Ｌ和１６１ｋＵ／Ｌ±１１３ｋＵ／Ｌ．显著高于正常对照组及消化道良性病变组（分别为５６ｋＵ／Ｌ±４４ｋＵ／Ｌ和５６ｋＵ／Ｌ±２１ｋＵ／Ｌ，Ｐ＜００１）．消化道肿瘤有腹腔及远处转移者，其血清ＣＡ５０含量升高更为明显．结论ＣＡ５０是较好的肿瘤标记物，有助于诊断消化道肿瘤．

AIM To evaluate the diagnostic value of carbohydrate antigen 50 in digestive neoplasm. METHODS Of the 172 patients with digestive neoplasm, 54 patients had primary liver cancer, 43 gastric carcinoma, 57 colorectal carcinoma and 18 pancreatic carcinoma. Eighty eight patients suffered from benign digestive disease, 36 of whom had cirrhosis, 52 gastritis or gastric ulcer. Sixty healthy persons served as controls. Samples of fasting blood were collected. Serum was separated and frozen at -20℃ until the analysis was made. The content of serum CA 50 was measured by RIA and the radioimmunoassay kit was provided by the Tumor Research Institute of the Chinese Academy of Medical Sciences useing FJ 630 counter. Data was expressed by ±s. +2s of control serum CA 50 was taken as upper limit to calculate the positive rates. RESULTS The contents of serum CA 50 in liver cancer, gastric carcinoma, pancreatic carcinoma and colorectal carcinoma were 24 0±21 8, 12 1±10 6, 18 2±10 7 and 16 1±11 3kU/L, being significantly higher than that in benign diseases and normal controls (5 6±4 4 and 5 6±2 1kU/L, P <0 01). When digestive tract malignant tumors metastasized in abdominal cavity and other sites, serum CA 50 was increased more significantly. CONCLUSION CA 50 is a better tumor marker. It is beneficial to diagnosis of digestive neoplasms.