摘要
目的探讨幽门螺杆菌(Hp)感染与胃癌部位及组织类型的关系.方法胃镜及病理证实的胃癌73例,男女之比为204∶1,平均年龄为560岁.其他肿瘤患者73例(食管癌22例;结直肠癌19例;肺癌21例;乳腺癌11例),男女之比为170∶1,平均年龄为556岁,进行1∶1病例一对照研究,采用间接ELISA法检测血清抗HpIgG抗体水平,将Hp抗体分为3个等级.结果胃癌组Hp感染率为589%,平均抗体水平为229±085(x±s),显著高于对照组的感染率425%(P<005)和平均抗体水平184±065(P<001).Hp感染率在对照组的分布情况为食管癌409%,结直肠癌474%,肺癌381%,乳腺癌455%.胃癌组与对照组相比,机会比值呈线性趋势(P=0005460).Hp阳性率在非贲门部胃腺癌为744%,明显高于贲门部腺癌407%(P<005).结论Hp感染与胃癌有关,特别与非贲门部腺癌关系密切.胃癌的危险性随抗HpIgG抗体滴度升高而升高.
AIM To investigate the relationship between Helicobacter pylori (Hp) infection, gastric carcinoma and its location and histological type. METHODS Seventy three patients with gastric carcinoma, with a ratio of male to female of 2 04∶1, mean age of 56 0 years, were confirmed by pathology and gastroscopy. Seventy three with other kinds of tumors (22 esophagus cancer, 19 rectocolonic cancer, 21 lung carcinoma, 11 breast cancer), the male to female ratia of 1 70∶1, the mean age 55 6 years, were studied with 1∶1 case matched controls. Indirect ELISA method was used to detect Hp IgG antibody in serum. Hp antibody was classified into three grades. RESULTS The positive rate of Hp infection and mean level of Hp IgG antibody were 58 9% and 2 29±0 85 ( ±s ) in gastric cancer group, which was significantly higher than that of the control group (42 5% and 1 84%±0 65, P <0 05 and P <0 01). The value of odds ratio (OR) of gastric carcinoma group has a linear tendency when it was compared with control group ( P =0 005460). Hp positive rate in non cardial gastric carcinoma was significantly higher than that of cardia adenocarcinoma (74 4% vs 40 7%, P <0 01). Positive rates of Hp infection in the control group were: esophagus cancer, 40 9%; rectocolonic cancer, 47 4%; lung carcinoma, 38 1%; and breast carcinoma, 45 5%. CONCLUSION Infection with Hp is associated with gastric carcinoma, and is strongly associated with non cardial adenocarcinoma. As the level of Hp IgG antibody increased, there was a progressive increase in the risk of gastric carcinoma.
关键词
胃肿瘤
癌
幽门螺杆菌感染
Helicobacter pylori \ \ Helicobacter infections/complications\ \ Stomach neoplasms/pathology