复方厄贝沙坦对轻中度高血压的控制率分析

The Analysis of Controlling Rate of Irbesartan/Hydrochlorothiazide Combination over Mild to Moderate Hypertension

目的：探讨复方厄贝沙坦片（厄贝沙坦氢氯噻嗪）对轻中度高血压控制的达标情况。方法：采用动态血压评价69例服用复方厄贝沙坦总的高血压患者的血压控制情况，服用剂量为1～2片，疗程6周。结果：服药后收缩压和舒张压的谷峰比值分别为0．69±0．19和0．67±0．25，服药前后24h血压负荷、平均压以及白昼和夜间平均血压均有明显变化，统计学分析差异显著（P〈0．01）。结论：复方厄贝沙坦片是一种有确切疗效的降压药物，有较好的谷峰比值，适宜临床选用。

Objective： To investigate the effect of irbesartan / hydrochlorothiazide combination over mild to moderate hypertension. Methods： 69 patients with hypertension were enrolled in this study and one to two pills of irbesartan / hydrochlorothiazide combination were given to them during six weeks. The antihypertensive efficacy of the combination of irbesartan and hydrochlorothiazide was assessed by 24 - hours ambulatory blood pressure monitoring. Results： The trough/peak ratio of irbesartan/ hydrochlorothiazide combination was 0.69±0.19 and 0.67± 0.25 respectively. There was very obvious statistical discrepancy between the 24 - hour blood pressure load, the 24 - hour average blood pressure and the day and night blood pressure before and after the use of irbesartan / hydrochlorothiazide combination. Conclusions： The irbesartan/ hydrochlorothiazide combination was a kind of effective drug with better trough/peak ratio.