元胡止痛分散片的家犬体内药动学研究

Pharmacokinetic Study of Yuanhu Zhitong Dispersible Tablets in Dogs

目的考察元胡止痛分散片的犬体内药动学，为临床用药提供实验依据。方法以普通片为对照，采用单剂量双周期交叉给药方案，以HPLC测定犬体内延胡索乙素的血浆浓度，并采用DASver1．0软件计算药动学参数。结果建立的HPLC可用于延胡索乙素的体内浓度分析；分散片的体内过程符合一室模型，tmax为0．75h，Cmax为269．80μg·L^-1，Kc为0．564h^-1，t1/2为1．773h，Ka为4．294h^-1，AUC0～8h为514．53μg·L^-1·h^-1。结论元胡止痛分散片较普通片吸收快，体现了分散片的剂型优势，也符合该制剂功能主治所需的快速起效。

OBJECTIVE To study the pharmacokinetics of Yuanhu Zhitong dispersible tablets in dogs. METHODS The tetrahydropalmatine concentration in plasm was determined by HPLC, pharmacokinetics parameters were calculated by DAS ver1. 0 software after dispersible and conventional tablets were given to dogs through single-dose, double-cycle crossing administration program. RE- SULTS The established HPLC method can be used for the determination of tetrahydropalmatine in plasm. The physiological disposition of Tetrahydropalmatine dispersible tablets fitted one-component model in vivo. The pharmacokinetics parameters of dispersible tablets, such as tmax, cmax Kc, t1/2, Ka and AUC0-8h was 0.75 h, 269.80 μg · L^-1 , 0.564 h^-1, 1. 773 h, 4. 294 h^-1, 514. 53 μg · L^-1 · h^-1. CONCLUSION The in vivo absorption of dispersible tablets is faster than that of conventional tablets. The result reflects the advantage of dispersible table form, and consistent with the requirement of quick action for threapy.