大肠癌患者手术前后血清胃泌素含量研究

Study on the contents of serum gastrin in patients with colorectal cancer

应用放射免疫分析法测定了４３例大肠癌患者手术前后和２０例对照组空腹血清胃泌素（ＳＧ）水平。结果表明：大肠癌患者ＳＧ显著高于对照组（Ｐ＜０．０１）；ＤｕｋｅｓＣ、Ｄ期大肠癌患者ＳＧ显著高于ＤｕｋｅｓＡ、Ｂ期（Ｐ＜０．０５）；不同肿瘤组织学类型之间ＳＧ差异无显著性；根治性大肠癌切除术后ＳＧ较术前显著降低（Ｐ＜０．０１）；姑息性手术前后ＳＧ差异无显著性。提示ＳＧ水平与大肠癌生长密切相关，ＳＧ测定有助于大肠癌诊断、治疗和预后的估计。

The level of fasting serum gastrin (SG) was measured in 43 patients with colorectal cancer before and after operation by radioimmunoassay. We found SG level in colorectal carcinoma was significantly higher than that in the control group ( P <0 01). Patients instage Dukes A.B had significantly lower contents of SG compared with instage C.D ( P <0 05). There was no significantly difference among different histological types of these patients. After operation SG level was marked elevated in radical operation ( P <0 01). There were no significant differences between preoperative and postoperative SG in palliative operation. The results indicates SG level was associated with the biological behavior of colorectal cancer. SG level may be useful in diagnosis, hoemone therapy and analysis of prognosis of colorectal cancer.